Synthesis, characterization, and antihyperglycemic activity of novel oxazolidine derivatives
| Autor: | Arumugam Siva Kumar, Palanirajan Vijayaraj Kumar, Parthasarathi Ramu, Theivendren Panneer Selvam |
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| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
Male Sucrose Oxazolidine endocrine system diseases Stereochemistry Pharmacology toxicology Rat model Streptozocin Diabetes Mellitus Experimental Rats Sprague-Dawley chemistry.chemical_compound Drug Discovery medicine Animals Hypoglycemic Agents Oxazoles Spectrum Analysis Organic Chemistry Streptozotocin Rats chemistry Molecular Medicine Oxazolidine derivatives medicine.drug |
| Zdroj: | Archives of Pharmacal Research. 34:887-891 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/s12272-011-0604-3 |
| Popis: | A number of compounds have been prepared in order to improve pharmacological roles of antihyperglycemic activity. In the present paper, a series of 3-benzyl-2-(4'-substituted phenyl)-4(5H)-(4″-nitrophenyl amino)-1,3-oxazolidines (6a-e) were tested against hyperglycemia. Their antihyperglycemic activity was evaluated by streptozotocin (STZ) and sucrose-loaded (SLM) models. Compounds 6a, b, c, d, and e displayed significant reductions in blood glucose in the streptozotocin and sucrose loaded rat models. The purity of the synthesized compounds was characterized by means of IR, (1)H-NMR, mass spectral and elemental analysis. |
| Databáze: | OpenAIRE |
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