Modeling knee osteoarthritis pathophysiology using an integrated joint system (IJS): a systematic review of relationships among cartilage thickness, gait mechanics, and subchondral bone mineral density
| Autor: | Patrick Omoumi, Brigitte M. Jolles, Thomas P. Andriacchi, Shannon N. Edd, Julien Favre |
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| Rok vydání: | 2018 |
| Předmět: |
Cartilage
Articular musculoskeletal diseases 0301 basic medicine Knee Joint Biomedical Engineering Osteoarthritis 03 medical and health sciences 0302 clinical medicine Rheumatology Bone Density medicine Humans Orthopedics and Sports Medicine Gait 030203 arthritis & rheumatology business.industry Cartilage Mechanics Osteoarthritis Knee Cartilage thickness musculoskeletal system Femoral cartilage medicine.disease Pathophysiology 030104 developmental biology medicine.anatomical_structure Mineral density Subchondral bone business human activities |
| Zdroj: | Osteoarthritis and Cartilage. 26:1425-1437 |
| ISSN: | 1063-4584 |
| Popis: | Summary Objective To introduce an integrated joint system (IJS) model of joint health and osteoarthritis (OA) pathophysiology through a systematic review of the cross-sectional relationships among three knee properties (cartilage thickness, gait mechanics, and subchondral bone mineral density). Methods Searches using keywords associated with the three knee properties of interest were performed in PubMed, Scopus, and Ovid databases. English-language articles reporting cross-sectional correlations between at least two knee properties in healthy or tibiofemoral OA human knees were included. A narrative synthesis of the data was conducted. Results Of the 5600 retrieved articles, 13 were included, eight of which reported relationships between cartilage thickness and gait mechanics. The 744 tested knees were separated into three categories based on knee health: 199 healthy, 340 at-risk/early OA, and 205 late OA knees. Correlations between knee adduction moment and medial-to-lateral cartilage thickness ratios were generally positive in healthy, inconclusive in at-risk/early OA, and negative in late OA knees. Knee adduction moment was positively correlated with medial-to-lateral tibial subchondral bone mineral density ratios in knees of all health categories. One study reported a positive correlation between lateral tibial subchondral bone mineral density and femoral cartilage thickness in at-risk/early OA knees. Conclusions The correlations identified between knee properties in this review agreed with the proposed relationship-based IJS model of OA pathophysiology. Accordingly, the IJS model could provide insights into overcoming current barriers to developing disease-modifying treatments by considering multiple aspects of OA disease, aspects that could be assessed simultaneously at an in vivo system level. |
| Databáze: | OpenAIRE |
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