Augmented anabolic responses after 8-wk cycling with blood flow restriction
| Autor: | Conceição, Miguel Soares, Mendes, Telles, Guilherme Defante, Libardi, Cleiton Augusto, Castro, Alex, Andrade, André L. L., Brum, Patrícia Chakur, Urias, Úrsula, Kurauti, Mirian Ayumi, Costa, Boschero, Antonio Carlos, Cavaglieri, Cláudia Regina, Camera, Donny M., Chacon-Mikahil, Mara Patricia Traina, Junior, Edson Manoel Mendes, Júnior, José Maria Costa |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty Anabolism Biopsy Physical Therapy Sports Therapy and Rehabilitation Blood flow restriction Quadriceps Muscle law.invention Electron Transport Complex IV angiogenesis Oxygen Consumption vascular occlusion Randomized controlled trial Endurance training law Internal medicine medicine Humans cell signaling Orthopedics and Sports Medicine Muscle Strength RNA Messenger muscle hypertrophy Ultrasonography medicine.diagnostic_test business.industry EXERCÍCIO FÍSICO Resistance Training Cardiorespiratory fitness Adaptation Physiological Bicycling Cardiorespiratory Fitness Regional Blood Flow Physical Endurance Muscle strength Cardiology Cycling business low-intensity exercise |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Introduction: Low-intensity endurance training (ET) performed with blood flow restriction (BFR) can improve muscle strength, cross-sectional area (CSA) and cardiorespiratory capacity.Whether muscle strength and CSA as well as cardiorespiratory capacity (i.e.,V˙ O2max) and underlying molecular processes regulating such respective muscle adaptations are comparable to resistance and ET is unknown. Purpose: To determine the respective chronic (i.e., 8 wk) functional, morphological, and molecular responses of ET-BFR training compared with conventional, unrestricted resistance training (RT) and ET. Methods: Thirty healthy young men were randomly assigned to one of three experimental groups: ET-BFR (n = 10, 4 dIwkj1, 30-min cycling at 40% of V˙ O2max), RT (n = 10, 4 dIwkj1, 4 sets of 10 repetitions leg press at 70% of one repetition maximum with 60 s rest) or ET (n = 10, 4 dIwkj1, 30-min cycling at 70%ofV˙ O2max) for 8 wk. Measures of quadriceps CSA, leg press one repetition maximum, and V˙ O2max as well as muscle biopsies were obtained before and after intervention. Results: Both RT and ET-BFR increased muscle strength and hypertrophy responses. ET-BFR also increased V˙ O2max, total cytochrome c oxidase subunit 4 isoform 1 abundance and vascular endothelial growth factor mRNA abundance despite the lower work load compared to ET. Conclusions: Eight weeks of ET-BFR can increase muscle strength and induce similar muscle hypertrophy responses to RT while V˙ O2max responses also increased postintervention even with a significantly lower work load compared with ET. Our findings provide new insight to some of the molecular mechanisms mediating adaptation responses with ET-BFR and the potential for this training protocol to improve muscle and cardiorespiratory capacity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|