Initial Disease Course and Treatment in an Inflammatory Bowel Disease Inception Cohort in Europe : The ECCO-EpiCom Cohort
| Autor: | Doron Schwartz, Yaroslava Zhulina, Svetlana Turcan, Konstantinnos H. Katsanos, Matteo Martinato, Pekka Collin, Jóngerd Olsen, Vicent Hernandez, I. Kaimakliotis, Niels Thorsgaard, Alberto Fernandez, Ida Vind, Olga Shonová, Vibeke Andersen, Ebbe Langholz, Jens Kjeldsen, Adrian Goldis, Nikša Turk, Epameinondas V. Tsianos, L. Barros, Selwyn Odes, Limas Kupčinskas, Inna Nikulina, Elena Belousova, Riina Salupere, Fernando Magro, Laimas Virginijus Jonaitis, Dana Duricova, Laszlo Lakatos, Susanne Krabbe, Sven Almer, K. Ladefoged, Frederik Dahlerup Jens, Natalia Pedersen, Daniela Lazăr, Peter L. Lakatos, Colm O'Morain, Pia Munkholm, K R Nielsen, Johan Burisch, Pia Manninen, Søren Avnstrøm, S. Cukovic-Cavka, Jonas Halfvarson, Silvia Lombardini, Her Hsin Tsai, Shaji Sebastian, Y. Bailey |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Databases Factual Epidemiology Population Gastroenterology Inflammatory bowel disease Young Adult Internal medicine medicine Humans Immunology and Allergy Prospective Studies Prospective cohort study education Aged Aged 80 and over education.field_of_study Crohn's disease business.industry Incidence Incidence (epidemiology) Remission Induction digestive oral and skin physiology epidemiology outcomes research ulcerative colitis Middle Aged Inflammatory Bowel Diseases Prognosis medicine.disease Combined Modality Therapy Ulcerative colitis digestive system diseases Europe Outcomes research Cohort Disease Progression Female business Follow-Up Studies |
| Zdroj: | Burisch, J M, Pedersen, E N G, Cukovic-Cavka, S, Turk, N, Kaimakliotis, I, Duricova, D, Shonová, O, Vind, I, Avnstrøm, S, Thorsgaard, N, Krabbe, S, Andersen, V, Dahlerup Jens, F, Kjeldsen, J, Salupere, R, Olsen, J, Nielsen, K R, Manninen, P, Collin, P, Katsanos, K H, Tsianos, E V, Ladefoged, K D, Lakatos, L, Bailey, Y, O'Morain, C, Schwartz, D, Odes, S, Martinato, M, Lombardini, S, Jonaitis, L, Kupcinskas, L, Turcan, S, Barros, L, Magro, F, Lazar, D, Goldis, A, Nikulina, I, Belousova, E, Fernandez, A, Hernandez, V, Almer, S, Zhulina, Y, Halfvarson, J, Tsai, H-H, Sebastian, S, Lakatos, P L, Langholz, E, Munkholm, P & EpiCom Group 2014, ' Initial Disease Course and Treatment in an Inflammatory Bowel Disease Inception Cohort in Europe : The ECCO-EpiCom Cohort ', Inflammatory Bowel Diseases, vol. 20, no. 1, pp. 36-46 . https://doi.org/10.1097/01.MIB.0000436277.13917.c4 |
| DOI: | 10.1097/01.MIB.0000436277.13917.c4 |
| Popis: | The EpiCom cohort is a prospective, population-based, inception cohort of inflammatory bowel disease (IBD) patients from 31 European centers covering a background population of 10.1 million. The aim of this study was to assess the 1-year outcome in the EpiCom cohort. Patients were followed-up every third month during the first 12 (±3) months, and clinical data, demographics, disease activity, medical therapy, surgery, cancers, and deaths were collected and entered in a Web-based database (www.epicom- ecco.eu). In total, 1367 patients were included in the 1- year follow-up. In western Europe, 65 Crohn's disease (CD) (16%), 20 ulcerative colitis (UC) (4%), and 4 IBD unclassified (4%) patients underwent surgery, and in eastern Europe, 12 CD (12%) and 2 UC (1%) patients underwent surgery. Eighty-one CD (20%), 80 UC (14%), and 13 (9%) IBD unclassified patients were hospitalized in western Europe compared with 17 CD (16%) and 12 UC (8%) patients in eastern Europe. The cumulative probability of receiving immunomodulators was 57% for CD in western (median time to treatment 2 months) and 44% (1 month) in eastern Europe, and 21% (5 months) and 5% (6 months) for biological therapy, respectively. For UC patients, the cumulative probability was 22% (4 months) and 15% (3 months) for immunomodulators and 6% (3 months) and 1% (12 months) for biological therapy, respectively in the western and eastern Europe. In this cohort, immunological therapy was initiated within the first months of disease. Surgery and hospitalization rates did not differ between patients from eastern and western Europe, although more western European patients received biological agents and were comparable to previous population- based inception cohorts. |
| Databáze: | OpenAIRE |
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