Possible involvement of nonbilayer lipids in the stimulation of the activity of cytochrome P450SCC (CYP11A1) and its propensity to induce vesicle aggregation
| Autor: | Dieter Schwarz, Sandra Pisch, Pyotr Kisselev, Uwe T. Bornscheuer, R Wessel, Rolf D. Schmid |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
chemistry.chemical_classification
endocrine system Chemistry Cholesterol side-chain cleavage enzyme Vesicle Organic Chemistry Fatty acid Stimulation Cell Biology Cleavage (embryo) Biochemistry Nephelometry and Turbidimetry Liposomes Phosphatidylcholines Side chain Cholesterol Side-Chain Cleavage Enzyme CYTOCHROME P450SCC Dimyristoylphosphatidylcholine Molecular Biology Function (biology) |
| Zdroj: | Chemistry and Physics of Lipids. 85:91-99 |
| ISSN: | 0009-3084 |
| Popis: | Phosphatidylcholines with saturated branched fatty acyl chains substituted in the 2-positions of the main chains have a significant stimulating effect on both the side chain cleavage activity of cytochrome P450SCC and the ability of P450SCC to induce a specific vesicle aggregation in lipid-vesicle reconstituted systems. Stimulation increases with increasing content of the branched phosphatidylcholines and is sensitive to its acyl chain structure and composition. Because branched phosphatidylcholines containing 2-alkyl substituted fatty acid chains belong to a new class of phosphatidylcholines forming inverted nonbilayer phases the results indicate that nonbilayer lipids might play an important role in the function of mitochondrial P450SCC. |
| Databáze: | OpenAIRE |
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