Absorption of lithium following administration of slow-release and conventional preparations
| Autor: | Goodwin Jc, Nicholas J. Birch, Roy Hullin, Stephen Tyrer |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Drug
Adult Male Time Factors media_common.quotation_subject chemistry.chemical_element Administration Oral Biological Availability Absorption (skin) Lithium Absorption Excretion chemistry.chemical_compound Feces In vivo Humans Applied Psychology media_common Aged Chromatography Chemistry Lithium carbonate Middle Aged Psychiatry and Mental health Oral ingestion Delayed-Action Preparations Drug Evaluation Female |
| Zdroj: | Psychological medicine. 6(1) |
| ISSN: | 0033-2917 |
| Popis: | SynopsisThe plasma lithium levels of 18 subjects receiving one standard and two slow-release preparations of lithium carbonate were measured at frequent intervals during the 24 hours following oral ingestion of a single dose of the drug. Although the slow-release tablets showed slow-release in vitro, this was not so in vivo. One slow-release preparation, in particular, was ineffectively absorbed by some subjects. There was no difference in the rate of absorption and excretion between the other slow-release product and the standard BP preparation. The implications of the results are discussed. |
| Databáze: | OpenAIRE |
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