Plasma Indoleamine 2,3-Dioxygenase and Arginase Type I May Contribute to Decreased Blood T-Cell Count in Hemodialysis Patients

Autor:	Theodoros Eleftheriadis, Georgios Pissas, Ioannis Stefanidis, Georgia Antoniadi, Grammati Galaktidou, Efi Yiannaki, Vassilios Liakopoulos
Rok vydání:	2012
Předmět:	Male medicine.medical_specialty Arginine T-Lymphocytes medicine.medical_treatment T cell Apoptosis Enzyme-Linked Immunosorbent Assay Inflammation Adaptive Immunity Critical Care and Intensive Care Medicine Flow cytometry Renal Dialysis Internal medicine medicine Humans Indoleamine-Pyrrole 2 3 -Dioxygenase Lymphocyte Count Indoleamine 2 3-dioxygenase Arginase medicine.diagnostic_test business.industry General Medicine Middle Aged Flow Cytometry Prognosis Endocrinology medicine.anatomical_structure Nephrology Immunology Kidney Failure Chronic Female Hemodialysis medicine.symptom business Biomarkers Follow-Up Studies
Zdroj:	Renal Failure. 34:1118-1122
ISSN:	1525-6049 0886-022X
DOI:	10.3109/0886022x.2012.713297
Popis:	Acquired immunity is impaired in hemodialysis (HD) patients, and decreased T-cell number may contribute. Indoleamine 2,3-dioxygenase (IDO) and arginase type I (ARG) catabolize tryptophane and arginine, respectively, and exert proapoptotic and antiproliferative effects on T-cells. Plasma levels of IDO and ARG and their relation to blood T-cell number were evaluated in HD patients.Thirty-two HD patients and 20 healthy controls participated in the study. Plasma IDO and ARG were measured by means of enzyme-linked immunosorbent assay. T-cell number was assessed by means of flow cytometry.IDO concentration was significantly higher in HD patients than in healthy volunteers (44.30 ± 31.83 ng/mL vs. 21.28 ± 26.21 ng/mL, p = 0.009). There was a trend for higher ARG concentration in HD patients (13.43 ± 11.91 ng/mL) than in healthy volunteers (9.56 ± 4.03 ng/mL), which, however, did not reach statistic significance (p = 0.099). Absolute T-cell count was significantly lower in HD patients than in healthy controls (1176.99 ± 567.71 cells/mm3 vs. 1519.85 ± 594.96 cells/mm3, p = 0.040). Absolute blood T-cell number was inversely related to plasma IDO (r = -0.490, p = 0.004) and to plasma ARG (r = -0.387, p = 0.029) concentrations.Plasma IDO and ARG may contribute to decreased blood T-cell count in HD patients.
Databáze:	OpenAIRE
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