The Effects of Montelukast on Intradermal Wheal and Flare
| Autor: | Samuel L. Hill, John H. Krouse |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Cyclopropanes Hypersensitivity Immediate Male medicine.medical_specialty Adolescent Injections Intradermal Wheal and flare Acetates Sulfides Loratadine law.invention 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law Anti-Allergic Agents Candida albicans medicine Humans Prospective Studies 030223 otorhinolaryngology Montelukast Aged Skin Tests integumentary system Leukotriene Antagonists Leukotriene receptor business.industry Antagonist Follow up studies Rhinitis Allergic Seasonal Middle Aged Dermatology Otorhinolaryngology 030220 oncology & carcinogenesis Anesthesia Quinolines Female Surgery business Follow-Up Studies Histamine medicine.drug |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 129:199-203 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1016/s0194-5998(03)00607-7 |
| Popis: | We sought to determine the effect of montelukast, a leukotriene receptor antagonist, on intradermal skin testing. Study design and setting We conducted a prospective, randomized, double-blind, placebo-controlled study in a university setting.After a 1-week washout of allergy pharmacotherapy, intradermal skin testing was performed on 23 atopic subjects. Whealing size was measured 20 minutes after injection. Subjects then began a 1-week regimen of daily loratadine, montelukast, or placebo. At 1 week, subjects again underwent intradermal skin testing. The change in wheal size was then calculated from baseline.A significant difference (P0.05) between the montelukast and loratadine groups in suppression of intradermal whealing at 1 week was observed. No significant difference was noted between the montelukast and placebo subjects.Montelukast demonstrated no significant suppression of skin whealing after antigen challenge over placebo.Montelukast does not need to be discontinued before intradermal allergy testing. |
| Databáze: | OpenAIRE |
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