Pharmacokinetics of cefoxitin during haemofiltration
| Autor: | Alfonso Domínguez-Gil, María José López García, J. M. Tabernero, M. Diaz Molina |
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| Rok vydání: | 1983 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment Antibiotics Ultrafiltration Cefoxitin Pharmacokinetics Hemofiltration Humans Medicine Pharmacology (medical) In patient Pharmacology Chemotherapy business.industry General Medicine Cefoxitin Dose Surgery Kinetics Blood Anesthesia Kidney Failure Chronic business Beta lactam antibiotics medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 25:395-398 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/bf01037954 |
| Popis: | The pharmacokinetics of cefoxitin was studied in patients with renal impairment during haemofiltration and in the intervening periods after administration of 30 and 15 mg/kg of the drug, respectively. Different pharmacokinetic patterns were established during haemofiltration and in the interim period, with average elimination half-lives of 11.85 +/- 4.3 and 3.41 +/- 0.6 h, respectively. The average fraction of the cefoxitin dose eliminated in haemofiltration was 0.62 +/- 0.11, more than that established in haemodialysis. In patients with terminal renal impairment undergoing haemofiltration every 48 h, a dose of 15 or 30 mg/kg is recommended at the start and at the end of each haemofiltration session. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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