Penetration of ceftibuten into middle ear fluid
| Autor: | Chin-Chung Lin, Pramila Kumari, R J Perrotta, B E Reidenberg |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.drug_class
Cephalosporin Cmax Ear Middle Pharmacology Pharmacokinetics Oral administration otorhinolaryngologic diseases polycyclic compounds Humans Medicine Pharmacology (medical) Ceftibuten Chromatography High Pressure Liquid Antibacterial agent business.industry Area under the curve Infant Penetration (firestop) biochemical phenomena metabolism and nutrition Cephalosporins Otitis Media Infectious Diseases Child Preschool Anesthesia Acute Disease embryonic structures business Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 40:1394-1396 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.40.6.1394 |
| Popis: | The penetration of ceftibuten, an extended-spectrum oral cephalosporin, into middle ear fluid (MEF) was evaluated in pediatric patients during a course of daily oral doses of 9 mg/kg of body weight for 10 days. Plasma and MEF collected at 2, 4, 6, or 12 h after at least 3 days of dosing were analyzed for ceftibuten by a high-pressure liquid chromatography method, and the data were used to calculate pharmacokinetic parameters. Plasma and MEF had almost identical maximum concentrations (Cmax) of ceftibuten (14 micrograms/ml). These Cmax values in MEF during acute otitis media were well in excess of the MIC for 90% of the isolates of each of four major pathogens in this disease. The time to Cmax was longer in MEF (4 h) than in plasma (2 h). Excellent penetration (71%) of ceftibuten into MEF was observed on the basis of the area under the curve ratio (MEF/plasma). These data clearly indicate that ceftibuten penetrated well into the MEF to yield clinically effective concentrations. |
| Databáze: | OpenAIRE |
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