Anti-MDA5 antibody-positive rapidly progressive interstitial pneumonia without cutaneous manifestations
| Autor: | Masataka Kuwana, Toru Tanaka, Masahiro Seike, Nariaki Kokuho, Yoshinobu Saito, Hiroyuki Takoi, Hiroki Hayashi, Yasuhiro Terasaki, Takeru Kashiwada, Akihiko Gemma, Chika Yajima, Takahisa Gono, Junichi Aoyama, Shinji Abe, Ayumi Nishikawa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Cyclophosphamide medicine.medical_treatment Anti-MDA5 anti-melanoma differentiation-associate gene Case Report IVCY intravenous cyclophosphamide Gastroenterology Clinical amyopathic dermatomyositis 03 medical and health sciences 0302 clinical medicine Internal medicine CADM clinically amyopathic dermatomyositis RP-ILD rapidly progressive interstitial lung disease Extracorporeal membrane oxygenation Medicine lcsh:RC705-779 Inhalation biology Anti-melanoma differentiation-associated gene 5 antibody business.industry ARS anti-aminoacyl-tRNA synthetase Interstitial lung disease lcsh:Diseases of the respiratory system Dermatomyositis medicine.disease Tacrolimus RIG-I retinoic acid inducible gene-I respiratory tract diseases Rapidly progressive interstitial pneumonia 030228 respiratory system Methylprednisolone 030220 oncology & carcinogenesis biology.protein HRCT high-resolution computed tomography Antibody business medicine.drug |
| Zdroj: | Respiratory Medicine Case Reports, Vol 26, Iss, Pp 193-196 (2019) Respiratory Medicine Case Reports |
| ISSN: | 2213-0071 |
| Popis: | A 47-year-old man was referred to our hospital with a 1-month history of fever and dyspnea after inhalation of insecticide in a confined space. We diagnosed rapidly progressive interstitial pneumonia. High-dose methylprednisolone, tacrolimus, and intermittent infusion of cyclophosphamide were administered. His condition rapidly deteriorated; therefore, extracorporeal membrane oxygenation therapy was performed. Unfortunately, he died 69 days after admission. Although typical skin findings suggestive of dermatomyositis were absent, anti-melanoma differentiation-associate gene (anti-MDA5) antibody was positive. Our findings suggest that in patients with hyperferritinemia and rapidly progressive interstitial lung disease (RP-ILD) demonstrating random ground glass shadows and peripheral consolidations by high-resolution computed tomography (HRCT) even if skin manifestations related to dermatomyositis are not complicated, we should assume anti-MDA5 antibody-positive interstitial pneumonia. Keywords: Anti-melanoma differentiation-associated gene 5 antibody, Rapidly progressive interstitial pneumonia, Clinical amyopathic dermatomyositis, Extracorporeal membrane oxygenation |
| Databáze: | OpenAIRE |
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