mRNA Expression of Lysyl Oxidase and Matrix Metalloproteinase-12 in Mouse Skin
| Autor: | Mikako Sato, Yoshihisa Takahata, Eiichiro Onitsuka, Daichi Oikawa, Yoriko Akimoto, Mitsuhiro Furuse, Yurika Mizobe, Fumiki Morimatsu, Kousuke Hamasu, Shoichiro Tsuyama |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Lysyl oxidase Biology Matrix metalloproteinase Applied Microbiology and Biotechnology Biochemistry Gene Expression Regulation Enzymologic Analytical Chemistry Protein-Lysine 6-Oxidase Mice chemistry.chemical_compound Dermis Matrix Metalloproteinase 12 Gene expression medicine Animals RNA Messenger Molecular Biology Skin Sex Characteristics Messenger RNA Oxidase test integumentary system Organic Chemistry General Medicine Molecular biology Circadian Rhythm Desmosine medicine.anatomical_structure chemistry Female Elastic fiber Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 72:3067-3070 |
| ISSN: | 1347-6947 0916-8451 |
| DOI: | 10.1271/bbb.80450 |
| Popis: | Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period. |
| Databáze: | OpenAIRE |
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