Chronic mild prenatal stress exacerbates the allergen-induced airway inflammation in rats

Autor: Edson Antunes, Heloisa H.A. Ferreira, Nancy Airoldi Teixeira, Paulo Nogueira
Přispěvatelé: Universidade Estadual Paulista (Unesp), Universidade São Francisco (USF), Universidade Estadual de Campinas (UNICAMP)
Jazyk: angličtina
Rok vydání: 1999
Předmět:
cell infiltration
animal cell
lung lavage
stress
Leukocyte Count
Pregnancy
mononuclear cell
Medicine
rat
medicine.diagnostic_test
biology
respiratory system
Housing
Animal
medicine.anatomical_structure
priority journal
Prenatal Exposure Delayed Effects
Female
prenatal care
medicine.symptom
Bronchial Hyperreactivity
Prenatal stress
Eosinophils
Asthma
Development
Lungs
lcsh:RB1-214
Research Article
medicine.medical_specialty
Offspring
Ovalbumin
animal experiment
Immunology
Inflammation
Prenatal care
progeny
Peripheral blood mononuclear cell
animal tissue
Internal medicine
lcsh:Pathology
Animalia
Animals
eosinophil
Rats
Wistar
nonhuman
Water Deprivation
business.industry
animal model
prediction
Cell Biology
asthma
Eosinophil
Allergens
Rats
Pregnancy Complications
Endocrinology
Bronchoalveolar lavage
biology.protein
business
Food Deprivation
Stress
Psychological
Zdroj: Mediators of Inflammation
Mediators of Inflammation, Vol 8, Iss 2, Pp 119-122 (1999)
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 0962-9351
Popis: Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:19:44Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:45:10Z : No. of bitstreams: 1 2-s2.0-0032979193.pdf: 1430591 bytes, checksum: bc375c88aa37b5250f3ceb50a54aacfd (MD5) Made available in DSpace on 2014-05-27T11:19:44Z (GMT). No. of bitstreams: 0 Previous issue date: 1999-06-03 The effects of chronic mild prenatal stress on leukocyte infiltration into the airways was investigated in rat offspring. The chronic prenatal stress consisted of transitory and variable changes in the rat's living conditions. Offspring at adult age were actively sensitized (day 0) and intratracheally challenged (day 14) with ovalbumin. Bronchoalveolar lavage was performed in the offspring at 48 h after intratracheal challenge with ovalbumin. A significant increase in total leukocyte infiltration was observed in the non-stressed offspring group and this was associated with a marked recruitment of eosinophils without a significant effect on the influx of neutrophils and mononuclear cells. In the prenatal stressed offspring, the counts of both total leukocyte and eosinophils, as well as mononuclear cells, was increased by 50% compared to the non-stressed offspring. We provide here the first experimental evidence that chronic mild unpredictable prenatal stress produces a marked increase in the allergen-induced airway inflammation in the rat offspring. Departamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista, Botucatu, SP Universidade Sao Francisco, Bragança Paulista, SP Departamento de Farmacologia Faculdade de Ciências Medicas UNICAMP, P.O. Boc 6111, 13081-970 Campinas (SP) Departamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista, Botucatu, SP
Databáze: OpenAIRE
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