Effects of long-term low-dose corticosteroid therapy on humoral immunity
| Autor: | Mary E. Fedor, Arye Rubinstein |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cyclopropanes medicine.drug_class Immunology Acetates Sulfides Methylprednisolone Pneumococcal Vaccines Pharmacotherapy Immune system Nasal Polyps Immunity Agammaglobulinemia T-Lymphocyte Subsets Immunopathology Lymphopenia medicine Immunology and Allergy Humans Albuterol Anti-Asthmatic Agents Sinusitis B-Lymphocytes business.industry Common variable immunodeficiency Middle Aged medicine.disease Antibodies Bacterial Asthma Discontinuation Immunoglobulin G Humoral immunity Antibody Formation Quinolines Corticosteroid Drug Therapy Combination Female business Immunologic Memory |
| Zdroj: | Annals of allergy, asthmaimmunology : official publication of the American College of Allergy, Asthma,Immunology. 97(1) |
| ISSN: | 1081-1206 |
| Popis: | Background Corticosteroids are agents that suppress the immune system. Their suppressive activity is predominantly restricted to cell-mediated immunity, with a marginal inhibitory effect on humoral immunity. Objective To describe an acquired reversible B-cell deficiency in a patient treated with low-dose corticosteroids for 36 years. Methods A broad range of T- and B-cell parameters were studied over time, during and after discontinuation of corticosteroid therapy. Published works on this topic in animal and human models are reviewed. The findings unique to this patient are highlighted. Results While undergoing long-term corticosteroid therapy, a patient developed a clinical and immunologic picture suggestive of common variable immunodeficiency, with predominantly qualitative and quantitative B-cell abnormalities. These abnormalities resolved within 2 years after tapering of corticosteroid therapy. Conclusions Long-term low-dose corticosteroid use may reversibly decrease B-cell counts and specific antibody responses. |
| Databáze: | OpenAIRE |
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