Decreases in taurine levels induced by β-alanine treatment did not affect the susceptibility of tissues to lipid peroxidation
| Autor: | Jale Balkan, Semra Doğru-Abbasoğlu, Hande Parildar-Karpuzoglu, Mehmet Atilla Uysal, Gülçin Aykaç-Toker |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Taurine Antioxidant medicine.medical_treatment Clinical Biochemistry Biochemistry Antioxidants Lipid peroxidation chemistry.chemical_compound Malondialdehyde Internal medicine Benzene Derivatives medicine Animals Rats Wistar chemistry.chemical_classification Lipid peroxide Glutathione peroxidase Organic Chemistry Hydrogen Peroxide Glutathione Oxidants Ascorbic acid Rats Endocrinology chemistry Organ Specificity beta-Alanine Lipid Peroxidation NADP |
| Zdroj: | Amino Acids. 32:115-119 |
| ISSN: | 1438-2199 0939-4451 |
| DOI: | 10.1007/s00726-005-0282-x |
| Popis: | We aimed to investigate the effect of decreased taurine levels on endogenous and induced lipid peroxide levels in liver, brain, heart and erythrocytes as well as prooxidant and antioxidant balance in the liver of rats administered beta-alanine (3%, w/v) in drinking water for 1 month to decrease taurine levels of tissues. This treatment caused significant decreases in taurine levels of liver (86%), brain (36%) and heart (15%). We found that endogenous and ascorbic acid-, NADPH- and cumene hydroperoxide-induced malondialdehyde (MDA) levels did not change in the liver, brain and heart homogenates following beta-alanine treatment. Also, H(2)O(2)-induced MDA levels remained unchanged in erythrocytes. In addition, we did not observe any changes in levels of MDA, diene conjugates, glutathione, alpha-tocopherol, ascorbic acid and the activities of superoxide dismutase, glutathione peroxidase and glutathione transferase in the liver. According to this, buffering or sequestering capacity of tissues to exogenous stimuli was not influenced by reduced taurine levels in tissues of rats. |
| Databáze: | OpenAIRE |
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