Pharmacology of a potential anti-parkinson agent: Tigloidine
| Autor: | I. Sanghvi, E. Bindler, Samuel Gershon |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Atropine
Bromides Central Nervous System Physostigmine Tremorine Pharmacology Autonomic Nervous System Parasympatholytic Nicotine Mice Dogs Species Specificity medicine Animals CATS business.industry Parasympatholytics Drug Synergism Rats Amphetamine Autonomic nervous system Cats Reflex business Drug Antagonism medicine.drug |
| Zdroj: | European Journal of Pharmacology. 4:246-253 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(68)90091-5 |
| Popis: | Pharmacological activity of tigloidine hydrobromide, a naturally occuring analogue of atropine, was investigated in mice, rats, cats and dogs. In mice it markedly antagonized the effects of physostigmine and tremorine but failed to protect the animals against nicotine toxicity. On the autonomic nervous system, it had a weak parasympatholytic and gangliolytic effect compared to atropine and scopolamine. It produced hypotension in the cat which was due to both peripheral and central actions of the drug. Tigloidine did not cause any behavioral abberations in cats and dogs. However, it potentiated the amphetamine-induced behavior changes in these animals. It caused potentiation of mono and polysynaptic reflexes in the cat. In view of the reported usefulness of tigloidine in the treatment of Parkinson's disease, its probable site and mode of action are discussed. |
| Databáze: | OpenAIRE |
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