Competing Endogenous RNA Networks as Biomarkers in Neurodegenerative Diseases
| Autor: | Ana C. Calvo, Leticia Moreno-García, Laura Moreno-Martínez, Janne M. Toivonen, Rosario Osta, Raquel Manzano, Paula Aparicio, Miriam de la Torre, Nora Molina, Pilar Zaragoza, Tresa López-Royo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
extracellular/circulating biomarkers
RNA editing mRNA ceRNA network (ceRNET) pseudogene Review Computational biology neurodegenerative diseases (NDDs) Biology Catalysis Inorganic Chemistry Transcriptome lcsh:Chemistry Circular RNA microRNA medicine Animals Humans Gene Regulatory Networks competing endogenous RNAs (ceRNA) Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy long non-coding RNA Competing endogenous RNA Mechanism (biology) Organic Chemistry Neurodegenerative Diseases circular RNA General Medicine medicine.disease Long non-coding RNA Computer Science Applications lcsh:Biology (General) lcsh:QD1-999 Spinocerebellar ataxia Cell-Free Nucleic Acids Biomarkers |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 9582, p 9582 (2020) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Protein aggregation is classically considered the main cause of neuronal death in neurodegenerative diseases (NDDs). However, increasing evidence suggests that alteration of RNA metabolism is a key factor in the etiopathogenesis of these complex disorders. Non-coding RNAs are the major contributor to the human transcriptome and are particularly abundant in the central nervous system, where they have been proposed to be involved in the onset and development of NDDs. Interestingly, some ncRNAs (such as lncRNAs, circRNAs and pseudogenes) share a common functionality in their ability to regulate gene expression by modulating miRNAs in a phenomenon known as the competing endogenous RNA mechanism. Moreover, ncRNAs are found in body fluids where their presence and concentration could serve as potential non-invasive biomarkers of NDDs. In this review, we summarize the ceRNA networks described in Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis and spinocerebellar ataxia type 7, and discuss their potential as biomarkers of these NDDs. Although numerous studies have been carried out, further research is needed to validate these complex interactions between RNAs and the alterations in RNA editing that could provide specific ceRNET profiles for neurodegenerative disorders, paving the way to a better understanding of these diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|