Masculinizing sclerosing stromal tumor of the ovary during pregnancy
| Autor: | Alan W. Cashell, Margaret L. Cohen |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Stromal cell media_common.quotation_subject Population Ovary Cytokeratin Pregnancy Internal medicine medicine Humans education Menstrual cycle hirsutism media_common Ovarian Neoplasms education.field_of_study Sex Characteristics business.industry Hyperandrogenism Obstetrics and Gynecology medicine.disease Endometrial hyperplasia Endocrinology medicine.anatomical_structure Oncology Female business Pregnancy Complications Neoplastic |
| Zdroj: | Gynecologic oncology. 43(3) |
| ISSN: | 0090-8258 |
| Popis: | Sclerosing stromal cell tumors of the ovary are an uncommon neoplasm that usually does not produce hormonal imbalances. Most patients showing a hormonal effect from this lesion have had menstrual cycle disturbances. Infertility and endometrial hyperplasia have also been described. One other reported case had masculinizing effects. Other authors have documented elevated levels of both estrogenic and androgenic hormones that corrected after surgery. A case of a pregnant 27-year-old Caucasian with hirsutism on her chin and neck and a male suprapubic hair pattern is presented. Elevated androstenedione, dehydroepian-drosterone, and free testosterone levels were present. A 3-cm left ovarian mass was excised and identified as a sclerosing stromal tumor. The histologic features included a pseudolobular pattern with focal areas of sclerosis and a two-cell population of spindled and polygonal cells. Immunohistochemical studies showed a positive vimentin reaction, weakly positive desmin and muscle-specific actin stains, and a negative cytokeratin stain. Following surgery the hormone levels returned to normal and the hirsutism resolved. A normal female infant without evidence of masculinization was delivered from the patient at term. |
| Databáze: | OpenAIRE |
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