Synthetic and therapeutic perspectives of nitrogen containing heterocycles as anti-convulsants
| Autor: | Gourav Grover, Rohit Bhatia, Jawaid Akhtar, Rajarshi Nath |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Gabapentin
medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Pharmacology 01 natural sciences Biochemistry Vigabatrin Felbamate Structure-Activity Relationship chemistry.chemical_compound Epilepsy Heterocyclic Compounds Seizures Drug Discovery medicine Animals Humans Potency Oxcarbazepine Molecular Biology Molecular Structure 010405 organic chemistry Retigabine Organic Chemistry medicine.disease 0104 chemical sciences 010404 medicinal & biomolecular chemistry Anticonvulsant chemistry Molecular Medicine Anticonvulsants medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry. 28:115585 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2020.115585 |
| Popis: | Epilepsy is one of the commonly prevailing neurological disorders. According to the reports, it is evident that about 80% of the epileptic cases have been observed in developing countries. Although there are many drugs with significant potency available in the market; still there is an issue of selectivity and toxicity. Therefore, continuous attempts have been made by the researchers to develop newer therapeutic agents against epilepsy. Many synthetic strategies have been available in the literature to synthesize various classes of anticonvulsants with promising activity. In the presented review, authors have summarized some newer synthetic routes being used for the synthesis of nitrogen-containing anticonvulsants taking a cue from the reported established anticonvulsant drugs viz. vigabatrin, sodium valproate, oxcarbazepine, felbamate, retigabine, and gabapentin. Various derivatives with the substitution for better anticonvulsant profile have been described in the figures for easy comparative study. The structure-activity relationship (SAR) of compounds with maximum potency has also been discussed. This article may serve as a boost for the researchers to modify the pre-existing synthetic routes as well as to improve potency and yield of the compounds. |
| Databáze: | OpenAIRE |
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