Experimental allergic encephalomyelitis in non-human primates: diffusion imaging of acute and chronic brain lesions
| Autor: | J Peterson, S Cosgrove, Y He, Aaron C. Heide, Kenneth I. Marro, Ellsworth C. Alvord, K Petersen, Todd L. Richards, L. M. Rose |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Pathology medicine.medical_specialty Internal capsule Encephalomyelitis Autoimmune Experimental Multiple Sclerosis Diffusion Encephalomyelitis Brain damage 03 medical and health sciences 0302 clinical medicine Demyelinating disease medicine Animals 030212 general & internal medicine medicine.diagnostic_test business.industry Multiple sclerosis Brain Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Intensity (physics) Disease Models Animal Macaca fascicularis Neurology Acute Disease Chronic Disease Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Multiple sclerosis (Houndmills, Basingstoke, England). 1(2) |
| ISSN: | 1352-4585 |
| Popis: | Diffusion imaging and T2-weighted magnetic resonance imaging were performed on 16 monkeys with experimental allergic encephalomyelitis (EAE), a model of the human demyelinating disease MS. The purpose of this study was to determine whether local changes in diffusion image intensity could be correlated with the formation of acute and chronic demyelinating lesions. Diffusion image analysis was restricted to the internal capsule of the brain because of its anatomic orientation offiber pathways. Acute inflammatory EAE lesions were large and monophasic, as visualized by T2-weighted MRI, and were accompanied by a decrease in the diffusion MR image signal with the diffusion-sensitizing gradient in ail three orthogonal directions (n=27 brain regions, P |
| Databáze: | OpenAIRE |
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