Pre-imaginal exposure to Oberon® disrupts fatty acid composition, cuticular hydrocarbon profile and sexual behavior in Drosophila melanogaster adults
| Autor: | Jean-Pierre Farine, Z.C. Hamida, J.F. Ferveur, Noureddine Soltani |
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| Přispěvatelé: | Badji Mokhtar-Annaba University, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), The National Fund for Scientific Research of Algeria (NS), CNRS and Burgundy Regional Council (JPF and JFF), University of Burgundy (for ZCH, JPF and JFF) and the Ministry of Higher Education and Scientific Research of Algeria (PRFU project to NS). |
| Rok vydání: | 2021 |
| Předmět: |
Male
0106 biological sciences Insecticides medicine.medical_specialty Physiology Health Toxicology and Mutagenesis Animal Scales Biology Toxicology 01 natural sciences Biochemistry Sexual Behavior Animal 03 medical and health sciences sexual behavior Internal medicine Lipid biosynthesis Melanogaster medicine Animals Spiro Compounds Mode of action 030304 developmental biology 0303 health sciences Larva cuticular hydrocarbons Fatty Acids fungi Acetyl-CoA carboxylase toxicity Lipid metabolism Cell Biology General Medicine biology.organism_classification spiromesifen Hydrocarbons [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology 010602 entomology Drosophila melanogaster Endocrinology Toxicity Female |
| Zdroj: | Comparative Biochemistry and Physiology-Part C: Toxicology and Pharmacology Comparative Biochemistry and Physiology-Part C: Toxicology and Pharmacology, Elsevier, 2021, 243, pp.108981. ⟨10.1016/j.cbpc.2021.108981⟩ |
| ISSN: | 1532-0456 |
| DOI: | 10.1016/j.cbpc.2021.108981 |
| Popis: | International audience; Oberon® is a commercial formulation of spiromesifen, a pesticide inhibitor of lipid biosynthesis via acetyl CoA carboxylase, widely used in agricultural crop protection. However, its mode of action requires further analysis. We currently examined the effect of this product on Drosophila melanogaster as a non-target and model organism. Different concentrations of spiromesifen were administered by ingestion (and contact) during pre-imaginal development, and we evaluated its delayed action on adults. Our results suggest that spiromesifen induced insecticidal activity on D. melanogaster. Moreover, spiromesifen treatment significantly increased the duration of larval and pupal development at all tested concentrations while it shortened longevity in exposed males as compared to control males. Also, pre-imaginal exposure to spiromesifen quantitatively affected fatty acids supporting its primary mode of action on lipid synthesis. In addition, this product was found to modify cuticular hydrocarbon profiles in exposed female and male flies as well as their sexual behavior and reproductive capacity. |
| Databáze: | OpenAIRE |
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