Serum secretory immunoglobulins in ankylosing spondylitis
| Autor: | Wendling D, Seilles E, Didier Jm |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Secretory component Immunoglobulins Blood Sedimentation Arthritis Rheumatoid Rheumatology Internal medicine medicine Humans Spondylitis Ankylosing Secretory IgA Mucosal immunity Ankylosing spondylitis biology business.industry General Medicine Middle Aged medicine.disease Pathophysiology Immunoglobulin A Secretory Component C-Reactive Protein Immunoglobulin M Rheumatoid arthritis Immunoglobulin A Secretory Immunology biology.protein Female Antibody business |
| Zdroj: | Clinical Rheumatology. 15:590-593 |
| ISSN: | 1434-9949 0770-3198 |
| DOI: | 10.1007/bf02238549 |
| Popis: | Humoral mucosal immunity may be implicated in pathophysiology of ankylosing spondylitis (AS). The aim of the study was to evaluate serum levels of IgA, IgM and secretory IgA (sIgA), secretory IgM (sIgM) as well as free secretory component (FSC) in patients with AS compared to controls and rheumatoid arthritis (RA) patients. Levels of sIgA, sIgM and FSC were measured with a specific ELISA in 37 AS patients, 45 controls and 27 RA. The results were as follows: Serum levels of IgA were higher in AS vs controls and in RA vs controls (p = 0.01). Levels of sIgA were higher in AS vs controls (p = 0.01), but higher in RA vs AS (p = 10(-4)). There was no difference of sIgM in AS vs controls, FSC levels were higher in AS vs controls, and higher in AS patients with elevated CRP. In view of elevated FSC, this increase of sIgA in AS may have been due to excessive production of mucosal IgA after bacterial stimulation according to the current hypothesis of the disease. |
| Databáze: | OpenAIRE |
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