Evaluation of Late Adverse Events in Long-Term Wilms' Tumor Survivors
| Autor: | Flora E. van Leeuwen, Richard C. Heinen, Huib N. Caron, Caro C.E. Koning, Helena J H van der Pal, Foppe Oldenburger, Leontien C.M. Kremer, Mathilde C. Cardous-Ubbink, Irma W. E. M. van Dijk, Jan de Kraker, M.M. Geenen |
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| Přispěvatelé: | Epidemiology and Data Science, EMGO - Quality of care, CCA -Cancer Center Amsterdam, APH - Amsterdam Public Health, Radiotherapy, Paediatric Oncology, ARD - Amsterdam Reproduction and Development |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Neoplasms Radiation-Induced Adolescent Epidemiologic Factors medicine.medical_treatment Kidney Cardiovascular System Severity of Illness Index Wilms Tumor Bone and Bones Young Adult Severity of illness medicine Humans Anthracyclines Radiology Nuclear Medicine and imaging Survivors Young adult Child Radiation Injuries Adverse effect Lung Radiation business.industry Infant Neoplasms Second Primary Radiotherapy Dosage Wilms' tumor medicine.disease Kidney Neoplasms Hypoplasia Surgery Radiation therapy Fertility Oncology Child Preschool Cohort Radiology business Kidney disease |
| Zdroj: | van Dijk, I W E M, Oldenburger, F, Cardous-Ubbink, MC, Geenen, M M, Heinen, RC, de Kraker, J, van Leeuwen, F E, van der Pal, H J H, Caron, H N, Koning, C C E & Kremer, L C M 2010, ' Evaluation of late adverse events in long-term wilms' tumor survivors ', International journal of radiation oncology, biology, physics, vol. 78, no. 2, pp. 370-378 . https://doi.org/10.1016/j.ijrobp.2009.08.016 International journal of radiation oncology, biology, physics, 78(2), 370-378. Elsevier Inc. |
| ISSN: | 0360-3016 |
| Popis: | Purpose: To evaluate the prevalence and severity of adverse events (AEs) and treatment-related risk factors in long-term Wilms' tumor (WT) survivors, with special attention to radiotherapy. Methods and Materials: The single-center study cohort consisted of 185 WT survivors treated between 1966 and 1996, who survived at least 5 years after diagnosis. All survivors were invited to a late-effects clinic for medical assessment of AEs. AEs were graded for severity in a standardized manner. Detailed radiotherapy data enabled us to calculate the equivalent dose in 2 Gy fractions (EQD(2),) to compare radiation doses in a uniform way. Risk factors were evaluated with multivariate logistic regression analysis. Results: Medical follow-up was complete for 98% of survivors (median follow-up, 18.9 years; median attained age, 22.9 years); 123 survivors had 462 AEs, of which 392 had Grade 1 or 2 events. Radiotherapy to flank/abdomen increased the risk of any AE (OR, 1.08 Gy(-1) [CI, 1.04-1.13]). Furthermore, radiotherapy to flank/abdomen was associated with orthopedic events (OR, 1.09 Gy(-1) [CI, 1.05-1.13]) and second tumors (OR, 1.11 Gy(-1) [CI, 1.03-1.19]). Chest irradiation increased the risk of pulmonary events (OR, 1.14 Gy(-1) [CI, 1.06-1.21]). Both flank/abdominal and chest irradiation were associated with cardiovascular events (OR, 1.05 Gy(-1) [CI, 1.00-1.101, OR, 1.06 Gy(-1) [CI, 1.01-1.12]) and tissue hypoplasia (OR, 1.17 Gy(-1) [CI, 1.10-1.24], OR 1.10 Gy(-1) [CI, 1.03-1.18]). Conclusion: The majority of AEs, overall as well as in irradiated survivors, were mild to moderate. Nevertheless, the large amount of AEs emphasizes the importance of follow-up programs for WT survivors. (C) 2010 Elsevier Inc |
| Databáze: | OpenAIRE |
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