Lung Cancer Mortality in a District of La Spezia (Italy) Exposed to Air Pollution from Industrial Plants
| Autor: | Marina Vercelli, F. Pensa, Elsa Garrone, Vincenzo Fontana, Claudia Benco, Riccardo Puntoni, Michela Franchini, Roberta Baldi, Stefano Parodi |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lung Neoplasms Urban Population Population Environmental pollution Incineration Risk Assessment 030218 nuclear medicine & medical imaging 03 medical and health sciences symbols.namesake 0302 clinical medicine Risk Factors Environmental protection Air Pollution Environmental health Epidemiology medicine Humans Industry Poisson Distribution Poisson regression Sex Distribution education Aged Inhalation Exposure education.field_of_study business.industry Smoking Confounding Absolute risk reduction Confounding Factors Epidemiologic General Medicine Middle Aged Italy Socioeconomic Factors Oncology 030220 oncology & carcinogenesis Relative risk symbols Female Risk assessment business Power Plants |
| Zdroj: | Tumori Journal. 90:181-185 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089160409000204 |
| Popis: | Aims and background In the last decades, many epidemiological studies have implicated outdoor environmental carcinogens in the onset of lung cancer. The present investigation evaluated lung cancer mortality in two areas of the Province of La Spezia (Northern Italy) exposed to environmental pollution emitted by a coal-fired power station and other industrial sources, including a waste incinerator. Methods In the two exposed areas, lung cancer mortality risk for the 1988-1996 calendar period was evaluated using the whole Province population as referent. The corresponding relative risks (RR) were estimated after controlling for age structure, urban/rural gradient and deprivation factors (occupation, education, home ownership, housing conditions and family structure) by a Poisson regression modeling. The geographic pattern of risk for the whole province was evaluated via the Besag, York and Mollié (BYM) bayesian model. Results Persons living in urban areas showed the highest rates in both sexes. No statistically significant risk excess was found in the two exposed areas among males, after excluding rural and semi-rural zones from the analyses (RR = 1.03 and RR = 0.77). In contrast, a risk excess was observed for females in both exposed areas, which remained elevated and statistically significant (P Conclusions The risk observed among females is consistent with pollution measurements and with other epidemiologic findings, whereas a strong confounding from occupational exposures and smoking habit could account for the lack of an excess risk in males. However, the ecologic nature of this investigation prevented drawing a causal inference. The pollution-related risk observed in the female gender is an important clue that deserves further epidemiologic attention. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|