Lymphoid chemokines in chronic neuroinflammation
| Autor: | Diego Franciotta, Barbara Serafini, Roberta Magliozzi, Eliana M. Coccia, Elena Ambrosini, Francesca Aloisi, Barbara Rosicarelli, Sandra Columba-Cabezas, Richard Reynolds, Marco Salvetti |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Central Nervous System
Chemokine Encephalomyelitis Autoimmune Experimental Immunology chemokines Inflammation multiple sclerosis Article Epstein–Barr virus medicine Animals Humans inflammation lymphoid neogenesis Epstein-Barr virus Immunology and Allergy Lymphocytes CXCL13 Neuroinflammation biology Multiple sclerosis Experimental autoimmune encephalomyelitis Innate lymphoid cell medicine.disease Chemokine CXCL13 Disease Models Animal Lymphatic system Neurology biology.protein Neurology (clinical) medicine.symptom epstein-barr virus |
| Zdroj: | Journal of Neuroimmunology |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2008.04.025 |
| Popis: | Lymphoid chemokines play an essential role in the establishment and maintenance of lymphoid tissue microarchitecture and have been implicated in the formation of tertiary (or ectopic) lymphoid tissue in chronic inflammatory conditions. Here, we review recent advances in lymphoid chemokine research in central nervous system inflammation, focusing on multiple sclerosis and the animal model experimental autoimmune encephalomyelitis. We also highlight how the study of lymphoid chemokines, particularly CXCL13, has led to the identification of intrameningeal B-cell follicles in the multiple sclerosis brain paving the way to the discovery that these abnormal structures are highly enriched in Epstein–Barr virus-infected B cells and plasma cells. |
| Databáze: | OpenAIRE |
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