Photoactivation of Vascular iNOS and Elevation of cGMP In Vivo: Possible Mechanism for Photovasorelaxation and Inhibition of Restenosis in an Atherosclerotic Rabbit Model¶
| Autor: | Gary S. Roubin, Nicholas Kipshidze, Chandramallika Ghosh, Jeffrey W. Moses, Patrick L. Iversen, Michael H. Keelan, John R. Petersen, Jafar Vossoughi, Ivan Bachutashvili, John W. Karanian, Martin B. Leon |
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| Rok vydání: | 2007 |
| Předmět: |
Iliac artery
Pathology medicine.medical_specialty biology Anatomy General Medicine medicine.disease Balloon Biochemistry Nitric oxide synthase chemistry.chemical_compound Restenosis chemistry In vivo medicine Rabbit model biology.protein Laser illumination Physical and Theoretical Chemistry Cyclic guanosine monophosphate |
| Zdroj: | Photochemistry and Photobiology. 72:579-582 |
| ISSN: | 0031-8655 |
| DOI: | 10.1562/0031-8655(2000)0720579poviae2.0.co2 |
| Popis: | Recently, intravascular low-power red laser light (LPRLL) therapy has been proposed for the prevention of postangioplasty restenosis due to the observed inhibition of experimental neointimal formation. The objective of this study was to determine the impact of endoluminal LPRLL on vascular levels of inducible nitric oxide synthase (iNOS) and cyclic guanosine monophosphate (cGMP) to help define the mechanism of this effect. Eight atherosclerotic male adult New Zealand White rabbits weighing 4–6 kg were used in these studies. The iliac arteries were treated in separate zones with: (1) balloon inflation only; (2) laser illumination only; and (3) balloon inflation + laser illumination. An uninjured zone of the iliac artery served as a control. Laser irradiation (630 nm) was delivered to the vessel wall via a Cold™ laser Illuminator (Cook, Inc., Bloomington, IN), with a 3 mm–diameter balloon. Experiments demonstrated that vascular cGMP levels obtained immediately following treatment in the balloon onl... |
| Databáze: | OpenAIRE |
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