Neurochemical alterations in frontal cortex of the rat after one week of hypobaric hypoxia
| Autor: | Perry F. Renshaw, Volodymyr B. Bogdanov, Andrew P. Prescot, Osama Abdullah, Olena V. Bogdanova, Shami Kanekar |
|---|---|
| Přispěvatelé: | Brain Institute, Vanderbilt University [Nashville], Department of Bioengineering, University of Utah, Nutrition et Neurobiologie intégrée (NutriNeuro), Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Centre National de la Recherche Scientifique (CNRS), Taras Shevchenko National University of Kyiv, Department of Radiology, VISN19 MIRECC Salt Lake City UAMC, Partenaires INRAE, Utah Science, Technology, and Research (USTAR) initiative, VISN19 Mental Illness Research Education and Clinical Center (MIRECC), VA Merit Review grant [5I01 CX000812, DA031247] |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Magnetic Resonance Spectroscopy Time Factors Central nervous system Glycine Glutamic Acid Creatine Hippocampus Article Rats Sprague-Dawley Behavioral Neuroscience chemistry.chemical_compound Neurochemical Internal medicine medicine Animals depression hypobaric hypoxia behavior proton magnetic resonance spectroscopy Hypoxia Swimming Depressive Disorder Alanine business.industry Altitude Glutamate receptor Anatomy Effects of high altitude on humans Hypoxia (medical) Corpus Striatum Frontal Lobe Rats Endocrinology medicine.anatomical_structure chemistry Frontal lobe Female [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] medicine.symptom business Inositol Behavioural despair test |
| Zdroj: | Behavioural Brain Research Behavioural Brain Research, Elsevier, 2014, 263, pp.203-209. ⟨10.1016/j.bbr.2014.01.027⟩ |
| ISSN: | 0166-4328 1872-7549 |
| DOI: | 10.1016/j.bbr.2014.01.027 |
| Popis: | International audience; Residing at high altitude may lead to reduced blood oxygen saturation in the brain and altered metabolism in frontal cortical brain areas, probably due to chronic hypobaric hypoxia. These changes may underlie the increased rates of depression and suicidal behavior that have been associated with life at higher altitudes. To test the hypothesis that hypobaric hypoxia is responsible for development of mood disorders due to alterations in neurochemistry, we assessed depression-like behavior in parallel to levels of brain metabolites in rats housed at simulated altitude. 32 female Sprague Dawley rats were housed either in a hypobaric hypoxia chamber at 10,000 ft of simulated altitude for 1 week or at local conditions (4500 ft of elevation in Salt Lake City, Utah). Depression-like behavior was assessed using the forced swim test (FST) and levels of neurometabolites were estimated by in vivo proton magnetic resonance spectroscopy in the frontal cortex, the striatum and the hippocampus at baseline and after a week of exposure to hypobaric hypoxia. After hypoxia exposure the animals demonstrated increased immobility behavior and shortened latency to immobility in the FST. Elevated ratios of myo-inositol, glutamate, and the sum of myo-inositol and glycine to total creatine were observed in the frontal cortex of hypoxia treated rats. A decrease in the ratio of alanine to total creatine was also noted. This study shows that hypoxia induced alterations in frontal lobe brain metabolites, aggravated depression-like behavior and might be a factor in increased rates of psychiatric disorders observed in populations living at high altitudes. |
| Databáze: | OpenAIRE |
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