Are Measurements of Urine Enzymes Useful during Aminoglycoside Therapy?
| Autor: | Thomas F. Boat, Pi Wan Cheng, Stephen H. Powell, Michael D. Reed, Robert C. Stern, Mary W Vermeulen |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Lung Diseases Male medicine.medical_specialty Adolescent Cystic Fibrosis Glycoside Hydrolases Urology Urine Kidney Cystic fibrosis Nephrotoxicity Excretion chemistry.chemical_compound Acetylglucosaminidase medicine Humans Pseudomonas Infections Child Blood urea nitrogen alpha-L-Fucosidase Creatinine Proteinuria business.industry Aminoglycoside Middle Aged beta-Galactosidase medicine.disease Surgery Aminoglycosides chemistry Child Preschool Pediatrics Perinatology and Child Health Tobramycin Female Muramidase Gentamicins medicine.symptom business |
| Zdroj: | Pediatric Research. 15:1234-1239 |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | We prospectively evaluated concentrations of beta-D-galactosidase, alpha-L-fucosidase, beta-D-N-acetylglucosaminidase, and lysozyme in urine from normal subjects, ambulatory patients with cystic fibrosis (CF), and CF patients with previously normal renal function who were receiving intravenous aminoglycoside (AG) therapy. Enzyme activities were generally low or negligible in subjects not receiving AG. Enzymuria was documented during 12 of 13 AG treatment courses and most frequently involved beta-D-N-acetylglucosaminidase excretion. In nine courses, enzymuria occurred in the absence of proteinuria or elevations of blood urea nitrogen and serum creatinine. In three courses attended by enzymuria and evidence of nephrotoxicity, neither the time of appearance nor the magnitude of enzymuria was different from that of nonnephrotoxic patients. In two of these three treatment courses, enzymuria preceded clinical evidence of nephrotoxicity of 16 and 5 days, and in the third course enzymuria and elevation of blood urea nitrogen and serum creatinine occurred simultaneously. We conclude that enzymuria is not a reliable predictor of nephrotoxicity due to AG in CF patients and is not an indication of discontinue AG therapy. |
| Databáze: | OpenAIRE |
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