Delayed Diagnosis of Respiratory Syncytial Virus Infections in Hospitalized Adults: Individual Patient Data, Record Review Analysis and Physician Survey in the United States

Autor: Nelson Lee, Roman Fleischhackl, David Myers, Jessica Zakar, Edward E. Walsh, Robert Stolper, Ian Sander, Veronique Wyffels
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Pediatrics
Delayed Diagnosis
diagnosis
respiratory syncytial virus
Antibiotics
Medical Records
law.invention
0302 clinical medicine
law
Surveys and Questionnaires
Prevalence
Immunology and Allergy
Medicine
030212 general & internal medicine
Respiratory system
Respiratory Tract Infections
Aged
80 and over
Vaccines
record review
Respiratory tract infections
Middle Aged
Intensive care unit
Hospitalization
Intensive Care Units
Infectious Diseases
Hospital admission
Female
Seasons
Adult
medicine.medical_specialty
Adolescent
medicine.drug_class
030106 microbiology
Respiratory Syncytial Virus Infections
Delayed diagnosis
Virus
03 medical and health sciences
Young Adult
Major Articles and Brief Reports
Physicians
Humans
Aged
business.industry
Diagnostic Tests
Routine
Patient data
United States
Respiratory Syncytial Virus
Human
acute respiratory infection
business
Zdroj: The Journal of Infectious Diseases
ISSN: 1537-6613
Popis: Background Despite the prevalence of respiratory syncytial virus (RSV) in adults hospitalized with acute respiratory infections, guidelines for the diagnosis and management of RSV have not been established. This analysis evaluated the role and timeliness of RSV diagnostic testing and its potential impact on clinical outcomes. Methods We analyzed individual patient data from hospitalized adults with confirmed RSV infections during 2 North American RSV seasons. Participating physicians reported clinical, virologic diagnosis, and outcome variables using a standardized online case form. Results Across 32 US states, 132 physicians reported 379 RSV cases. Polymerase chain reaction–based diagnostics were the most common type of test ordered (94.2%) with 24 hours after hospital admission, respectively. Later diagnosis was associated with longer hospital stays (n = 145; R = +0.191; P < .05) and greater antibiotic use. Conclusion Diagnosis of RSV infection in hospitalized adults is often delayed, which may affect clinical management and outcomes. Our findings indicate the need to improve the diagnostic strategies in this patient population.
Diagnosis of respiratory syncytial virus infection in hospitalized adults is often delayed, which may affect clinical management and outcomes such as hospital stays and antibiotic use. Our findings indicate the need to improve the diagnostic strategies in this patient population.
Databáze: OpenAIRE
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