Prevalence of molecular markers of antimalarial drug resistance across altitudinal transmission zones in Highland Western Uganda
| Autor: | Jonathan J. Juliano, Nicholas F Brazeau, Travis Fulton, Edgar Mulogo, Moses Ntaro, Michael Matte, Nicholas J. Hathaway, Ross M. Boyce |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Genetic Markers
Plasmodium falciparum 030231 tropical medicine Drug Resistance Protozoan Proteins Drug resistance law.invention Antimalarials 03 medical and health sciences 0302 clinical medicine Altitude Ecological relationship law Virology parasitic diseases Prevalence Humans Uganda Malaria Falciparum River valley Geography biology Resistance (ecology) Ecology Membrane Transport Proteins Chloroquine Articles biology.organism_classification Phenotype Infectious Diseases Transmission (mechanics) Mutation Parasitology Spatial variability |
| Zdroj: | Am J Trop Med Hyg |
| DOI: | 10.17615/n46w-g515 |
| Popis: | We explored spatial variation in the prevalence of established molecular markers of antimalarial resistance across a geographically diverse, highland region of western Uganda. We identified Plasmodium falciparum CQ resistance transporter 76T mutations in all pools, but there was no evidence of spatial differences across village-based strata defined by either altitude or river valley. In contrast, we identified a significant inverse association between altitude and the prevalence of Plasmodium falciparum multidrug resistance 1 mutations with the largest proportion of Y184F mutations observed in the low-elevation, high-transmission villages. These results demonstrate the substantial heterogeneity in resistance markers observed across geographic settings, even at relatively small scales, but highlight the complex nature of these ecological relationships. |
| Databáze: | OpenAIRE |
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