Muscarinic and nicotinic receptors synergistically modulate working memory and attention in humans
| Autor: | Julia R. Ellis, Kathryn A. Ellis, Fiona F Erskine, Ben J. Harrison, Keith Wesnes, Pradeep J. Nathan, Cali F. Bartholomeusz, Luis Vitetta |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Time Factors Scopolamine Muscarinic Antagonists Nicotinic Antagonists Pharmacology Mecamylamine Neuropsychological Tests Receptors Nicotinic Flicker Fusion Double-Blind Method Muscarinic acetylcholine receptor medicine Muscarinic acetylcholine receptor M4 Reaction Time Humans Pharmacology (medical) Attention Drug Interactions Nicotinic Antagonist Receptor Acetylcholine receptor Pain Measurement Analysis of Variance Working memory Recognition Psychology Receptors Muscarinic Psychiatry and Mental health Nicotinic agonist Memory Short-Term Female Psychology Neuroscience Psychomotor Performance medicine.drug |
| Zdroj: | The international journal of neuropsychopharmacology. 9(2) |
| ISSN: | 1461-1457 |
| Popis: | Functional abnormalities in muscarinic and nicotinic receptors are associated with a number of disorders including Alzheimer's disease and schizophrenia. While the contribution of muscarinic receptors in modulating cognition is well established in humans, the effects of nicotinic receptors and the interactions and possible synergistic effects between muscarinic and nicotinic receptors have not been well characterized in humans. The current study examined the effects of selective and simultaneous muscarinic and nicotinic receptor antagonism on a range of cognitive processes. The study was a double-blind, placebo-controlled, repeated measures design in which 12 healthy, young volunteers completed cognitive testing under four acute treatment conditions: placebo (P); mecamylamine (15 mg) (M); scopolamine (0.4 mg i.m.) (S); mecamylamine (15 mg)/scopolamine (0.4 mg i.m.) (MS). Muscarinic receptor antagonism with scopolamine resulted in deficits in working memory, declarative memory, sustained visual attention and psychomotor speed. Nicotinic antagonism with mecamylamine had no effect on any of the cognitive processes examined. Simultaneous antagonism of both muscarinic and nicotinic receptors with mecamylamine and scopolamine impaired all cognitive processes impaired by scopolamine and produced greater deficits than either muscarinic or nicotinic blockade alone, particularly on working memory, visual attention and psychomotor speed. These findings suggest that muscarinic and nicotinic receptors may interact functionally to have synergistic effects particularly on working memory and attention and suggests that therapeutic strategies targeting both receptor systems may be useful in improving selective cognitive processes in a number of disorders. |
| Databáze: | OpenAIRE |
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