Analysis of Risk Factors for Changes in the Renal Two-Dimensional Image in Gout Patients
| Autor: | Wantai Dang, Xiaohui Xu, Danling Luo, Jian Liu, Jingguo Zhou, Jin Hu, Hui Luo, Lan-Lan You |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Renal cortex kidney stones Aspartate transaminase International Journal of General Medicine Gastroenterology two-dimensional ultrasound chemistry.chemical_compound gout Internal medicine medicine Original Research Creatinine Kidney biology business.industry nutritional and metabolic diseases renal cortex General Medicine medicine.disease Gout medicine.anatomical_structure chemistry Cystatin C renal medulla biology.protein Uric acid Kidney stones business |
| Zdroj: | International Journal of General Medicine |
| ISSN: | 1178-7074 |
| Popis: | Wantai Dang,1,* Xiaohui Xu,2,* Danling Luo,2 Hui Luo,2 Jin Hu,2 Jingguo Zhou,1 Jian Liu,2 Lanlan You2 1Department of Rheumatism and Immunity, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, Peopleâs Republic of China; 2Department of Ultrasound, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Lanlan You Email 17027279@qq.comObjective: To explore the effects of different blood uric acid levels in gout patients on the two-dimensional image of the kidney and the risk factors for gout-related kidney damage for providing clinical evidence to enable early prevention and treatment of gout-related kidney damage.Methods: We obtained information of 227 patients with primary gout and estimated the association between two-dimensional kidney images and clinical indicators using binary logistic regression.Results: Our study showed that different uric acid levels, age, disease course, cystatin C (CysC) level, and γ-glutamyl transpeptidase level were correlated with echo of the renal medulla (P < 0.05). CysC level was correlated with the renal cortex thickness and kidney stones in different uric acid-level groups (P < 0.05). Disease course, aspartate transaminase (AST) level, creatinine (CREA) level, and tophi were risk factors for renal cortex thinning in gout patients (P = 0.045, 0.026, 0.004, 0.006, respectively). The disease course, platelet (PLT) count, and high-density lipoprotein (HDL-C) level were risk factors for kidney stone formation in gout patients (P = 0.037, 0.022, 0.023, respectively), while CysC level and C-reactive protein (CRP) level were risk factors for increased renal medulla echo in these patients (P = 0.022, 0.028, respectively).Conclusion: Our study revealed disease course, AST level, CREA level, tophi, PLT count, HDL-C level, CysC level and CRP level may be important predictors of renal image changes.Keywords: gout, two-dimensional ultrasound, renal medulla, renal cortex, kidney stones |
| Databáze: | OpenAIRE |
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