Psychotropic drugs and ventricular repolarisation: The effects on QT interval, T-peak to T-end interval and QT dispersion
| Autor: | M. Lupi, Rosa Di Scala, Eduardo Cinosi, Massimo Di Giannantonio, Fabrizio Ricci, Giovanni Martinotti, T. Acciavatti, Raffaele De Caterina, M. Corbo, Emilia D’Ugo, Viola De Francesco |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Risk QT interval medicine.medical_specialty Heart Ventricles 030204 cardiovascular system & hematology QT dispersion repolarisation Sudden cardiac death T-peak to T-end ventricular Pharmacology Psychiatry and Mental Health Pharmacology (medical) 03 medical and health sciences Electrocardiography 0302 clinical medicine Internal medicine medicine Humans Psychotropic Drugs business.industry Middle Aged medicine.disease Increased risk Cross-Sectional Studies Death Sudden Cardiac Qt dispersion Cardiology Interval (graph theory) Female business 030217 neurology & neurosurgery Methadone |
| Popis: | Objective: We aimed to investigate in a clinical setting, the effects of different classes of psychotropic drugs on cardiac electrophysiological measures linked with an increased risk of sudden cardiac death. Methods: We conducted a cross-sectional study in a population of 1059 psychiatric inpatients studying the effects of various psychotropic drugs on the T-peak to T-end (TpTe) interval, QT dispersion and QT interval. Results: Methadone use showed a strong association with TpTe prolongation (odds ratio (OR)=12.66 (95% confidence interval (CI), 3.9–41.1), pConclusions: Treatment with psychotropic drugs influences TpTe and QT dispersion. These parameters might be considered to better estimate the sudden cardiac death risk related to specific medications. Beyond antipsychotics and antidepressants, mood stabilisers determine significant effects on ventricular repolarisation. |
| Databáze: | OpenAIRE |
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