Human papillomavirus does not play a role in the Barrett esophagus: a French cohort
| Autor: | Sandrine Bertrais, M. Le Rhun, Françoise Lunel-Fabiani, Nina Dib, Adeline Pivert, Dominique Luet, E. Cesbron-Metivier, Emmanuel Coron, C. Couffon, Sophie Michalak, Charlène Brochard, André Ricard, Alexandra Ducancelle, F.-X. Caroli Bosc, M. Bodin, Nicolas Musquer |
|---|---|
| Přispěvatelé: | CHU Pontchaillou [Rennes], Foie, métabolismes et cancer, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Neuropathies du système nerveux entérique et pathologies digestives, implication des cellules gliales entériques, Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Biopsy [SDV.CAN]Life Sciences [q-bio]/Cancer Real-Time Polymerase Chain Reaction Gastroenterology Virus Barrett's esophagus Barrett Esophagus 03 medical and health sciences Esophagus 0302 clinical medicine Internal medicine Prevalence medicine Humans Prospective Studies Human papillomavirus human papillomavirus HPV DNA Papillomaviridae Aged Hyperplasia business.industry Papillomavirus Infections HPV infection General Medicine [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Middle Aged medicine.disease humanities 3. Good health medicine.anatomical_structure Dysplasia Case-Control Studies 030220 oncology & carcinogenesis Cohort Etiology Female 030211 gastroenterology & hepatology France business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | Diseases of the Esophagus Diseases of the Esophagus, Wiley, 2017, 30 (11), pp.1-7. ⟨10.1093/dote/dox088⟩ Diseases of the Esophagus, 2017, 30 (11), pp.1-7. ⟨10.1093/dote/dox088⟩ |
| ISSN: | 1442-2050 1120-8694 |
| Popis: | International audience; The role of human papillomavirus (HPV) in Barrett's esophagus (BE) has been examined but remains unclear. The purpose of the study is to dispute the connection between HPV and BE in a prospective case-control study. Biopsies were performed above and inside the Barrett's segment for BE patients and in the distal third of the esophagus for control patients for histological interpretation and for virological analysis. Biopsies for virological analysis were placed in a virus transport medium and immediately frozen in liquid nitrogen. Virological analysis involved real-time PCR using the SyBr® green protocol with modified SPF10 general primers. A total of 180 patients (119 control and 61 BE, respectively) were included. In BE patients, 31, 18, and 12 patients had, respectively, no dysplasia, low-grade dysplasia, and high grade dysplasia. Overall, nine were found to be HPV positive: five were control patients and four BE patients. HPV positive status was not associated with BE. No factors were associated with HPV, in particular the degree of BE dysplasia. HPV infection appears unlikely to be significant in the etiology of BE compared with control patients. (ClinicalTrials.gov, Number NCT02549053). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|