Successful treatment of chronic hepatitis C virus infection in severely opioid-dependent patients under heroin maintenance
| Autor: | Bernd Schulte, Sabine Schütt, Jochen Brack, Peter Deibler, Jens Reimer, Uwe Verthein, Konrad Isernhagen, Christian Haasen, Christoph Dilg |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Narcotics medicine.medical_specialty Genotype Health Status Hepatitis C virus Hepacivirus Toxicology medicine.disease_cause Antiviral Agents Heroin Young Adult chemistry.chemical_compound Pharmacotherapy Pegylated interferon Germany Internal medicine Ribavirin medicine Humans Pharmacology (medical) Substance Abuse Intravenous Pharmacology Response rate (survey) Heroin Dependence business.industry Hepatitis C Middle Aged Viral Load medicine.disease Psychiatry and Mental health Mental Health chemistry Immunology Female Interferons Substance Abuse Treatment Centers Opiate business medicine.drug |
| Zdroj: | Drug and Alcohol Dependence. 109:248-251 |
| ISSN: | 0376-8716 |
| DOI: | 10.1016/j.drugalcdep.2010.01.009 |
| Popis: | Severely opioid-dependent patients are at high risk of both acquiring and spreading the hepatitis C virus (HCV). It is uncertain, however, whether these patients are possible candidates for HCV treatment. We therefore explored treatment retention and adherence as well as sustained viral response in co-morbid severely opioid-dependent subjects under heroin maintenance, who previously failed in conventional substitution treatment or were not in any drug treatment.All patients in heroin maintenance in the German heroin trial, who received standard antiviral HCV therapy with pegylated interferon and ribavirin, were included. Co-consumption of licit and illicit drugs was tolerated as long as it did not interfere with treatment.Twenty-six patients in heroin maintenance were treated for chronic HCV infection. Both the Global Severity Index of the Symptom Checklist 90-R (average score 65.9) and the Opiate Treatment Index (average score 16.6) indicated relevant co-morbidity. Twenty-one patients (81%) were retained in treatment; the adherence rate was 92%. Eighteen patients (69%) achieved a sustained viral response, with a 100% response rate for genotype 2, 90% for genotype 3, and 42% for genotype 1.This is the first study that investigates the feasibility of antiviral HCV treatment in a well-defined sample of co-morbid severely opioid-dependent subjects in heroin maintenance treatment. Viral response rates are comparable to non-drug-user populations. Within a need-adapted treatment setting, HCV treatment may even be extended to difficult-to-treat opioid-dependent patients. |
| Databáze: | OpenAIRE |
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