Preparation and characterization of selenium-rich polysaccharide from Phellinus igniarius and its effects on wound healing
| Autor: | Yuanyuan Gao, Guangtao Jia, Li Guo, Sai Zhang, Zhiqin Gao, Lujun Luo, Tongyi Sun, Yuxia Wang, Weiping Lin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Antioxidant Chromatography Gas Polymers and Plastics medicine.medical_treatment Anti-Inflammatory Agents 02 engineering and technology 010402 general chemistry Polysaccharide 01 natural sciences Antioxidants chemistry.chemical_compound Mice Selenium Malondialdehyde Spectroscopy Fourier Transform Infrared Materials Chemistry medicine Animals Phellinus igniarius Peroxidase Skin chemistry.chemical_classification Reactive oxygen species Glutathione Peroxidase Wound Healing biology Chemistry Glutathione peroxidase Organic Chemistry Fungal Polysaccharides 021001 nanoscience & nanotechnology biology.organism_classification Catalase 0104 chemical sciences Biochemistry Phellinus Myeloperoxidase biology.protein Wounds and Injuries 0210 nano-technology Reactive Oxygen Species |
| Zdroj: | Carbohydrate polymers. 264 |
| ISSN: | 1879-1344 |
| Popis: | The modified of polysaccharides show various bio-activities. In our work, Phellinus igniarius Selenium-enriched mycelias polysaccharides (PSeP) were prepared from Phellinus igniarius, and its antioxidant and anti-inflammatory effects on injured mice were evaluated. The selenium content and physical properties of polysaccharides were characterized by GC, HPGPC, and FT-IR analysis. The results showed that PSeP could reduce reactive oxygen species (ROS) levels, myeloperoxidase (MPO) activity as well as malondialdehyde (MDA) content. Meanwhile, it increased the enzyme activities of glutathione peroxidase (GSH-Px) and catalase (CAT). Finally, it showed obvious wound healing effects in vivo. Moreover, PSeP could clear the ROS without obvious cytotoxicity. PSeP could further improve its ability to clear ROS level to promote skin wound healing in mice three days in advance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect