| Autor: |
Moritz Ronicke, Andreas Baur, Michael Kirr, Michael Erdmann, Cornelia Erfurt‐Berge, Christian Ostalecki |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGReferences. 20(5) |
| ISSN: |
1610-0387 |
| Popis: |
Pyoderma gangrenosum is an ulcerative autoinflammatory disease, lacking distinct histopathological characteristics to differentiate from other ulcerating conditions, like venous leg ulcers. The objective of this study was therefore to find histopathological characteristics of pyoderma gangrenosum in a head-to-head comparison to venous leg ulcers.Eight tissue samples of pyoderma gangrenosum, twelve samples of venous leg ulcers and six samples of healthy skin were stained using an immunohistological multi antigen staining technology. The immune infiltrate and its spatial distribution were analyzed with contextual tissue cytometry software using fluorescence images.The dense epidermal presence of CD45ROThe histopathological differences found between pyoderma gangrenosum and venous leg ulcer can be used to distinguish between the two diseases and thus provide an important aid for the rapid initiation of adequate therapy. In addition, our data hint at an antigen-driven process in the epidermis, possibly involving CD1a |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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