Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast
| Autor: | Gyungyub Gong, Sei Hyun Ahn, Sakari Knuutila, Jeong Mi Park, Kowan J. Jee |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Pathology medicine.medical_specialty comparative genomic hybridization Loss of Heterozygosity Breast Neoplasms allelic loss on 3p Biology DNA Copy Number Changes lcsh:RC254-282 Loss of heterozygosity Nucleic acid thermodynamics Phyllodes Tumor Phyllodes tumours medicine Humans lcsh:QH573-671 Allele skin and connective tissue diseases Alleles Chromosome Aberrations lcsh:Cytology Nucleic Acid Hybridization Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chromosomes Human Pair 1 Allelic Imbalance Disease Progression Female Other Chromosomes Human Pair 3 sense organs Abnormality Phyllodes tumour chromosome 1q21–q23 Microsatellite Repeats Comparative genomic hybridization |
| Zdroj: | Analytical Cellular Pathology, Vol 25, Iss 2, Pp 89-93 (2003) Analytical Cellular Pathology : the Journal of the European Society for Analytical Cellular Pathology |
| ISSN: | 0921-8912 |
| DOI: | 10.1155/2003/803192 |
| Popis: | We studied DNA copy number changes by CGH and allelic imbalance (AI) on 3p by LOH analysis on 22 phyllodes tumours (PT) of the breast in order to gain insight into the genetic basis of tumour progression in PT. Copy number changes were observed in 14 cases (63%). Gain in 1q with 1q21–23 as the minimal overlapping area was seen in 12 cases (55%). The gain was observed both in benign and malignant tumours. Our study did not reveal any DNA copy number changes or allelic loss on 3p. The results suggest that DNA copy number changes are not associated with the histological grade or clinical behaviour of PT and the chromosomal changes on 3p appear to be rare. Colour figure can be viewed onhttp://www.esacp.org/acp/2003/25‐2/jee.htm. |
| Databáze: | OpenAIRE |
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