CHMPions of repair: emerging perspectives on sensing and repairing the nuclear envelope barrier
| Autor: | Nicholas R. Ader, C. Patrick Lusk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Nuclear Envelope
Mitosis Endosomes Biology Models Biological ESCRT Article 03 medical and health sciences 0302 clinical medicine Inner membrane Animals Humans Nuclear pore 030304 developmental biology Karyopherin chemistry.chemical_classification 0303 health sciences Endosomal Sorting Complexes Required for Transport Cell Biology chemistry Biophysics Interphase Nucleoporin Nuclear transport 030217 neurology & neurosurgery |
| Zdroj: | Curr Opin Cell Biol |
| Popis: | Understanding how the integrity of the nuclear membranes is protected against internal and external stresses is an emergent challenge. Work reviewed here investigated the mechanisms by which losses of nuclear-cytoplasmic compartmentalization are sensed and ameliorated. Fundamental to these is spatial control over interactions between the endosomal sorting complexes required for transport machinery and LAP2-emerin-MAN1 family inner nuclear membrane proteins, which together promote nuclear envelope sealing in interphase and at the end of mitosis. We suggest that the size of the nuclear envelope hole dictates the mechanism of its repair, with larger holes requiring barrier-to-autointegration factor and the potential triggering of a postmitotic nuclear envelope reassembly pathway in interphase. We also consider why these mechanisms fail at ruptured micronuclei. Together, this work re-emphasizes the need to understand how membrane flow and local lipid metabolism help ensure that the nuclear envelope is refractory to mechanical rupture yet fluid enough to allow its essential dynamics. |
| Databáze: | OpenAIRE |
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