Enzymes in intestinal juice from patients with liver diseases and colon polyps: measurement of bilirubin, alkaline phosphatase, aspartate aminotransferase and lactate dehydrogenase
| Autor: | Han Ying, Yoshiko Tamai, Masami Yoshiike, Akihiro Munakata, Yutaka Yoshida, Fusako Ono, Hiromi Saitoh, Yoshiharu Uno |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
medicine.medical_specialty Carcinoma Hepatocellular Bilirubin Colonoscopy Colonic Polyps Biology General Biochemistry Genetics and Molecular Biology Liver disease chemistry.chemical_compound Internal medicine Lactate dehydrogenase medicine Humans Aspartate Aminotransferases Intestinal juice Aged chemistry.chemical_classification medicine.diagnostic_test L-Lactate Dehydrogenase Liver Diseases General Medicine Middle Aged medicine.disease Alkaline Phosphatase Colon polyps Intestines Enzyme Endocrinology chemistry Alkaline phosphatase |
| Zdroj: | The Tohoku journal of experimental medicine. 178(2) |
| ISSN: | 0040-8727 |
| Popis: | Since the amounts of hepatogenous enzymes discharged into the intestinal tract remain unknown, this study was initiated to evaluate the amounts of the enzymes in the intestinal tract. Whole gut lavage fluid (polyethyleneglycol electrolyte solution) was administered orally to 42 subjects, consisting of 5 patients with hepatoma, 10 with chronic hepatitis, 10 with colon polyps, and 17 control subjects without liver disease. Two hr after the large intestinal lavage, the digestive tract juice was aspirated by colonoscopy, and the bilirubin (Bil), alkaline phosphatase (ALP), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) in the aspirates were measured. A positive correlation between the AST and LDH values was found, and a significant difference in these values between the hepatic disorders and the normal controls was noticed. A significant positive correlation between the ALP and Bil values was found, and a statistical difference in these values between the group of colon polyps and the controls and other groups was observed. This lavage fluid technique enables to estimate the amounts of hepatic enzymes discharged into the intestinal tract, thereby opening a new avenue for future enzyme research. |
| Databáze: | OpenAIRE |
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