A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection
| Autor: | Marina Lobato Martins, Maria Clara Fernandes da Silva-Malta, Argus Leão Araújo, Fabíola Araújo Gonçalves, Maiara de Lourdes Botelho, Isabelle Rocha de Oliveira, Luciana de Souza Madeira Ferreira Boy, Hélinse Medeiros Moreira, Edel Figueiredo Barbosa-Stancioli, Maísa Aparecida Ribeiro, Daniel Gonçalves Chaves |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical, Volume: 55, Article number: e0239-2022, Published: 21 OCT 2022 |
| ISSN: | 1678-9849 0037-8682 |
| Popis: | Background: The inflammatory response plays a significant role in the outcome of coronavirus disease (COVID-19). Methods: We investigated plasma cytokine and chemokine concentrations in non-infected (NI), asymptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected blood donors (AS), and patients with severe COVID-19 (SC). Results: The SC group showed significantly higher levels of interleukin 6 (IL-6), IL-10, and CCL5 than the AS and NI groups. The SC and AS groups had considerably greater CXCL9 and CXCL10 concentrations than the NI group. Only NI and infected people showed separate clusters in the principal component analysis. Conclusions: SC, as well as AS was characterized by an inflammatory profile. |
| Databáze: | OpenAIRE |
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