A dual functional fluorogenic probe for visualization of intracellular pH and formaldehyde with distinct fluorescence signals
| Autor: | Jingyan Ge, Danqi Hong, Liquan Zhu, Qing Zhu, Zhenda Xie, Biao Yin, Jiajie Shen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
biology
Chemistry Intracellular pH Organic Chemistry Formaldehyde 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences Biochemistry Fluorescence 0104 chemical sciences HeLa chemistry.chemical_compound Biophysics Physical and Theoretical Chemistry 0210 nano-technology |
| Zdroj: | Organicbiomolecular chemistry. 16(25) |
| ISSN: | 1477-0539 |
| Popis: | In this study, a single fluorescent probe (DPFP) containing a 1,8-naphthalimide dye and a homoallylamino group for imaging pH and formaldehyde (FA) has been developed that exhibits significant blue fluorescence (λem at 455 nm) under acidic pH conditions (pH < 7.0) and green fluorescence (λem at 555 nm) in the presence of FA, respectively. Furthermore, probe DPFP was successfully applied to image acidic lysosomes and exogenous or endogenous FA in living HeLa cells. |
| Databáze: | OpenAIRE |
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