Elevated LGI1-IgG CSF index predicts worse neurological outcome

Autor:	Eoin P. Flanagan, Divyanshu Dubey, Andrew McKeon, Vanda A. Lennon, Anastasia Zekeridou, Masoud Majed, Sarah M. Jenkins, Colton J. Thoreson, Avi Gadoth, Christopher J. Klein, Sean J. Pittock
Rok vydání:	2018
Předmět:	0301 basic medicine medicine.medical_specialty Index (economics) business.industry General Neuroscience medicine.medical_treatment Immunotherapy Brief Communication Intrathecal Gastroenterology Subclass 03 medical and health sciences Titer 030104 developmental biology 0302 clinical medicine Text mining Modified Rankin Scale Internal medicine Medicine Neurology (clinical) Brief Communications business 030217 neurology & neurosurgery
Zdroj:	Annals of Clinical and Translational Neurology
ISSN:	2328-9503
DOI:	10.1002/acn3.561
Popis:	To determine whether CSF leucine‐rich glioma‐inactivated 1(LGI1)‐IgG titer, index or IgG subclass has prognostic significance, we tested serum and CSF specimens collected concomitantly from 39 seropositive patients. LGI1‐IgG index was elevated (>1) in 21 patients (54%), suggesting intrathecal synthesis. Patients with worse outcome at last follow‐up (modified Rankin Scale >2) had significantly higher index (median 6.57 vs. 0.5, P = 0.048) compared to those with better outcome. Higher CSF LGI1‐IgG4 subclass‐specific titer and index correlated with worse outcome (P
Databáze:	OpenAIRE
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