Plant Derived Natural Products against Pseudomonas aeruginosa and Staphylococcus aureus: Antibiofilm Activity and Molecular Mechanisms
Autor: | Antonio Fiorentino, Brigida D'Abrosca, Elisabetta Buommino, Monica Scognamiglio, Francesca Guzzo |
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Přispěvatelé: | Guzzo, Francesca, Scognamiglio, Monica, Fiorentino, Antonio, Buommino, Elisabetta, D’Abrosca, Brigida, Guzzo, F., Scognamiglio, M., Fiorentino, A., Buommino, E., D'Abrosca, B. |
Rok vydání: | 2020 |
Předmět: |
Staphylococcus aureus
plant-derived natural products Phytochemicals Pharmaceutical Science Human pathogen Review medicine.disease_cause biofilm Analytical Chemistry Microbiology lcsh:QD241-441 03 medical and health sciences Antibiotic resistance lcsh:Organic chemistry Drug Discovery medicine Humans flavonoid Physical and Theoretical Chemistry plant-derived natural product 030304 developmental biology 0303 health sciences biology 030306 microbiology Pseudomonas aeruginosa Organic Chemistry Biofilm quorum sensing Antimicrobial biology.organism_classification Anti-Bacterial Agents 3. Good health Quorum sensing antibiotic-resistance Chemistry (miscellaneous) Biofilms flavonoids Staphylococcus aureu Molecular Medicine terpenes Bacteria |
Zdroj: | Molecules Molecules, Vol 25, Iss 5024, p 5024 (2020) |
ISSN: | 1420-3049 |
Popis: | Bacteria are social organisms able to build complex structures, such as biofilms, that are highly organized surface-associated communities of microorganisms, encased within a self- produced extracellular matrix. Biofilm is commonly associated with many health problems since its formation increases resistance to antibiotics and antimicrobial agents, as in the case of Pseudomonas aeruginosa and Staphylococcus aureus, two human pathogens causing major concern. P. aeruginosa is responsible for severe nosocomial infections, the most frequent of which is ventilator-associated pneumonia, while S. aureus causes several problems, like skin infections, septic arthritis, and endocarditis, to name just a few. Literature data suggest that natural products from plants, bacteria, fungi, and marine organisms have proven to be effective as anti-biofilm agents, inhibiting the formation of the polymer matrix, suppressing cell adhesion and attachment, and decreasing the virulence factors’ production, thereby blocking the quorum sensing network. Here, we focus on plant derived chemicals, and provide an updated literature review on the anti-biofilm properties of terpenes, flavonoids, alkaloids, and phenolic compounds. Moreover, whenever information is available, we also report the mechanisms of action. |
Databáze: | OpenAIRE |
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