Oxytocin system social function impacts in children with attention-deficit/hyperactivity disorder
| Autor: | Belma Doğan Güngen, Mutlu Karkucak, Esengul Kayan, Tuğba Didem Kuşçu, Elif Erol Güler, Muhammed Ayaz, Gokhan Ocakoglu, Ayşe Burcu Ayaz, Tahsin Yakut, Sebla Gökçe |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Male medicine.medical_specialty Adolescent Turkey Single-nucleotide polymorphism Oxytocin Polymorphism Single Nucleotide polymorphism Cellular and Molecular Neuroscience Gene Frequency Internal medicine Genotype medicine SNP Attention deficit hyperactivity disorder ADHD Humans Genetic Predisposition to Disease Interpersonal Relations Allele gene Child Social Behavior Allele frequency Genetics (clinical) Genetics business.industry Schedule for Affective Disorders and Schizophrenia medicine.disease Oxytocin receptor oxytocin receptor Psychiatry and Mental health Attention Deficit Disorder with Hyperactivity Receptors Oxytocin Case-Control Studies Female business |
| Popis: | WOS: 000361221200011 PubMed ID: 26174935 To investigate relationships between the polymorphisms and social functioning of children with Attention Deficit/Hyperactivity Disorder (ADHD), according to the polymorphism of three oxytocin receptor (OXTR) genes (rs53576, rs13316193, and and rs2268493). A total of 198 childrenstudying in the same primary and secondary school and matched in terms of age and gender (99 ADHD, 99 control)were included in this study. The Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version was administered to establish the clinical diagnosis. The Social Reciprocity Scale (SRS) was applied to evaluate social functioning. The total genomic DNA was isolated from buccal mucosa samples. No significant differences were determined between the ADHD and control groups in terms of rs2268493, rs13316193, and rs53576 genotype distribution (P=0.078, P=0.330, and P=0.149, respectively). However, the control group T allele frequency in the OXTR Single Nucleotide Polymorphism (SNP) rs2268493 was significantly higher than the ADHD group (P=0.024). Compared to the control group, the ADHD group had a higher score on the SRS scale (SRS total; Z=-21,135, P |
| Databáze: | OpenAIRE |
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