Fine structural changes in the lateral vestibular nucleus of aging rats
| Autor: | Jaime Miquel, Jr Je Johnson |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
Cytoplasm Aging Pathology medicine.medical_specialty Biology Endoplasmic Reticulum Models Biological Inclusion bodies Lipofuscin Vestibular nuclei medicine Animals Nuclear membrane Cell Nucleus Inclusion Bodies Neurons Endoplasmic reticulum Cell Membrane Anatomy Vestibular Nuclei Axons Mitochondria Rats Lateral vestibular nucleus Cell nucleus medicine.anatomical_structure Nerve Degeneration Neuroglia Developmental Biology |
| Zdroj: | Mechanisms of Ageing and Development. 3:203-224 |
| ISSN: | 0047-6374 |
| DOI: | 10.1016/0047-6374(74)90017-7 |
| Popis: | The fine structure of the lateral vestibular nucleus was investigated in Sprague-Dawley rats, that were sacrified at 4 weeks, 6-8 weeks, 6-8 months, and 18-20 months of age. In the neuronal perikaria, the following age-associated changes were seen with increasing frequency with advancing age: rodlike nuclear inclusions and nuclear membrane invaginations; cytoplasmic dense bodies with the characteristics of lipofuscin; and moderate disorganization of the granular endoplasmic reticulum. Dense bodies were also seen in glial cells. Rats 18 to 20 months old showed dendritic swellings, axonal degeneration, and an apparent increase in the number of axosomatic synaptic terminals containing flattened vesicles (presumed to be inhibitory in function). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|