Correspondence on 'Tumour necrosis factor inhibitors slow radiographic progression in patients with ankylosing spondylitis: 18-year real-world evidence'
| Autor: | Zheng-Liang Zhang, Guohua Lv, Zhi-Hui Dai, Ming-Xiang Zou, Wei Huang, Jing Li |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Necrosis Radiography Immunology Osteoporosis Population General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine Immunology and Allergy Medicine Humans Spondylitis Ankylosing education Spondylitis 030203 arthritis & rheumatology Ankylosing spondylitis education.field_of_study business.industry Tumor Necrosis Factor-alpha Retrospective cohort study medicine.disease 030104 developmental biology Antirheumatic Agents Disease Progression Tumor necrosis factor alpha Tumor Necrosis Factor Inhibitors medicine.symptom business |
| Zdroj: | Annals of the rheumatic diseases. 81(12) |
| ISSN: | 1468-2060 |
| Popis: | We recently read with great interest the article by Koo et al .1 In this retrospective study, the authors evaluated the effect of tumour necrosis factor (TNF) inhibitors on radiographic progression in patients with ankylosing spondylitis (AS) using real-world patient data with long-term follow-up information. They found that the TNF inhibitors could significantly impede the radiographic progression of AS patients. We commend the authors for performing this important study as the results could be very helpful in guiding practice in clinics. However, we noticed that the authors did not clarify the influence of TNF inhibitors on osteoporosis or vertebral fracture risk on imagings in the patients. Osteoporosis is a commonly recognised problem in AS population, which can lead to serious consequences for the patients. For instance, patients with AS may have severe fractures and resulting neurological dysfunctions even after minor trauma due to osteoporosis. Similarly, AS patients may be vulnerable to … |
| Databáze: | OpenAIRE |
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