Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction

Autor:	Jiri Parenica, J Manousek, Krystyna Kluz, Petr Kala, Jolana Lipková, Anna Vasku, Martin Poloczek, Jindrich Spinar, Jiri Jarkovsky, Simona Littnerová, Lenka Kubková, Monika Pávková Goldbergová
Rok vydání:	2017
Předmět:	Adult Male 0301 basic medicine medicine.medical_specialty medicine.medical_treatment 030204 cardiovascular system & hematology Matrix metalloproteinase Biology Gastroenterology 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Risk Factors Internal medicine Matrix Metalloproteinase 13 Genotype Genetics medicine Humans Myocardial infarction Allele Alleles Aged Polymorphism Genetic Framingham Risk Score Hazard ratio Percutaneous coronary intervention Tissue Inhibitor of Metalloproteinases General Medicine Middle Aged Prognosis medicine.disease 030104 developmental biology Matrix Metalloproteinase 9 Conventional PCI ST Elevation Myocardial Infarction Female Matrix Metalloproteinase 1
Zdroj:	Journal of Applied Genetics. 58:331-341
ISSN:	2190-3883 1234-1983
DOI:	10.1007/s13353-016-0388-8
Popis:	The influence of polymorphisms in the large group of MMP and TIMP genes on clinical outcomes in patients after ST elevation myocardial infarction (STEMI) treated with primary PCI was analysed. In total, 550 consecutive Caucasian patients with STEMI were included in the present study, with a median of 32 months. We analysed 19 polymorphisms in the genes coding MMP and TIMP genes. The MMP-1 -519A/G and -422A/T polymorphisms are associated with combined endpoint after myocardial infarction. The hazard ratio for AT variant of MMP-1 -422A/T was 1.75 (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99e209986fb7b9817c5a62e048b3f81 https://doi.org/10.1007/s13353-016-0388-8 Zobrazit plný text záznamu Full text from SpringerLink