Association of genetic polymorphisms of GALNT3 and VDR with osteoporosis in postmenopausal women
| Autor: | Guorong Wang, Xun Zheng, Aimin Chen, Jiahua Zhu, Fangye Zhou, Wangqing Shi, Guoxian Chen, Junhua Yang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Osteoporosis Lumbar vertebrae Biology Calcitriol receptor Bone remodeling 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology (miscellaneous) Statistical significance Internal medicine medicine vitamin D receptor genetic polymorphism Femoral neck Bone mineral 030219 obstetrics & reproductive medicine multiple logistic regression analysis Articles General Medicine medicine.disease osteoporosis Menopause 030104 developmental biology medicine.anatomical_structure Endocrinology GALNT3 correlation serum calcium and phosphorus TaqMan genotyping technology bone turnover markers |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2016.3665 |
| Popis: | The correlation of genetic polymorphisms of GALNT3 and vitamin D receptor (VDR) with osteoporosis in postmenopausal women was investigated. A total of 1,212 cases of postmenopausal patients diagnosed with osteoporosis (observation group) and 404 cases of postmenopausal women without osteoporosis (control group) were selected. Dual-energy X-ray absorptiometry was used for measurement of bone mineral density (BMD) of lumbar vertebrae L2–4, proximal femoral neck and total hip, and classifications were made. TaqMan genotyping technology was employed to examine tag single-nucleotide polymorphism (tagSNP) of GALNT3 and VDR and the correlation of tagSNP with bone turnover markers (BTMs) and serum calcium and phosphorous levels was analyzed. The multiple logistic regression analysis was used to screen risk factors for osteoporosis. A comparison of age and menopause time of the two groups, yielded no statistical significance difference (P>0.05). BMD and T values of the lumbar vertebrae, femoral neck and total hip in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|