Transient anti-hepatitis C antibodies after influenza vaccination

Autor: Almog R, Gilon E, Shai Ashkenazi, Bar-Shany S
Rok vydání: 1994
Předmět:
Zdroj: Infection. 22:367-367
ISSN: 1439-0973
0300-8126
DOI: 10.1007/bf01715554
Popis: An increase from 0.4 to 0.8% was noted in the prevalence of antibodies against hepatitis C virtis (HCV) in blood donors serving in the Israel Defence Force (IDF) during the winter months. We also noted that many of the HCV-seropositive donors had had negative serologic results in a previous blood donation 6--11 months earlier. Knowing that influenza vaccination had been carried out in various IDF units during early winter, we studied the potential effects of influenza vaccination on HCV serology by ascertaining the vaccination history of the blood donors, repeating HCV serologic testing 4-5 months after the donation, and comparing results from several commercial kits. Included in the study were all soldiers who had donated blood in November and December 1992. HCV serology was routinely examined at the Magen David Adorn (MDA) Blood Services by second generation Abbott HCV EIA (Abbott Laboratories, USA) since August 1991. Fifty-three HCV-positive donors who were .either seronegative at the previous donation or first-time donors were identified, Of these, 39 were retested by the same commercial kits 4-5 months later; 29 were negative on the second test, and ten remained positive. Most of those who became seronegative (24/29, 83%) had received influenza vaccine (Pasteur M6rieux Serum & Vaccines, Lyon, France). Most (80%) of those who remained seropositive had initally high anti-HCV titers. Sixteen of the Abbott-positive samples were also tested at the same time with the Ortho second generation HCV kit (Ortho Diagnostics, USA) and 14 were found to be HCV-negative. Overall, less than 1% of those who had received the influenza vaccine had false-positive HCV serology results.
Databáze: OpenAIRE
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